Ponatinib Impurity 46 CAS CATO-C4X-226946
| CAS No. | CATO-C4X-226946 |
| Molecular Formula | C8H5N3 |
| Molecular Weight | 143.15 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Ponatinib Impurity 46.
As a process- or degradation-related impurity, Ponatinib Impurity 46 (CAS CATO-C4X-226946, C8H5N3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a nitrogen-containing heterocyclic scaffold, a nitrile group, Ponatinib Impurity 46 is typically pale yellow to yellow liquid. Its solid-state physicochemical attributes — including a molecular weight of 143.15 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Ponatinib Impurity 46 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H5N3 |
| Molecular Weight | 143.15 g/mol |
| Purity | ≥95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 3 |
Related Ponatinib Standards
- Ponatinib Impurity 32 (CAS CATO-C4X-226932)
- Ponatinib Impurity 35 (CAS CATO-C4X-226935)
- Ponatinib Impurity 37 (CAS 2098039-04-2)
- Ponatinib Impurity 40 (CAS CATO-C4X-226940)
- Ponatinib Impurity 36 (CAS CATO-C4X-226936)
- Ponatinib Impurity 39 (CAS 2702457-83-6)
- Ponatinib Impurity 41 (CAS CATO-C4X-226941)
- Ponatinib Impurity 2 (CAS CATO-C4X-22692)
Recommended Standards
- Upadacitinib Impurity 163 (CAS CATO-C4X-2405163)
- Methyl isothiazole-3-carboxylate (CAS 1001907-72-7)
- Pyridine-3-sulfinic acid (CAS 101084-77-9)
- Pyrrolo[1,2-c]pyrimidine-4-carbonitrile (CAS 52951-24-3)
- Atomoxetine Impurity 29 (CAS CATO-C4X-155029)
- Avibactam Impurity 146 (CAS CATO-C4X-1348146)
- Perindopril Impurity 103 (CAS CATO-C4X-1252103)
- Bis(perfluorohexyl)phosphinic Acid (CAS 40143-77-9)
- Afatinib Impurity 37 (CAS 372-19-0)
- 1-(4-Fluorophenyl)-N-methylpropan-1-amine (CAS 926262-89-7)
- 2-Formyl-3-hydroxybenzonitrile (CAS 1243286-54-5)
- 7-Chloro-5-iodo-1-(triisopropylsilyl)-1H-pyrrolo[2,3-c]pyridine (CAS 1198097-05-0)
- Paraquat diiodide D6 (CAS CATO-CCPD102175)
- Semaglutide impurity 86 (CAS CATO-C4X-222686)
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