Ponatinib Impurity 45 CAS CATO-C4X-226945
| CAS No. | CATO-C4X-226945 |
| Molecular Formula | C8H6I2O2 |
| Molecular Weight | 387.94 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Ponatinib Impurity 45 (C8H6I2O2) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, iodine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a process- or degradation-related impurity, Ponatinib Impurity 45 (CAS CATO-C4X-226945, C8H6I2O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO manufactures Ponatinib Impurity 45 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C8H6I2O2 |
| Molecular Weight | 387.94 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | ≥95% |
| Storage | Store at room temperature |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | I-containing |
Related Ponatinib Standards
- Ponatinib Impurity 31 (CAS CATO-C4X-226931)
- Ponatinib Impurity 9 (CAS CATO-C4X-22699)
- Ponatinib Impurity 42 (CAS CATO-C4X-226942)
- Ponatinib impurity 5 (CAS 122947-77-7)
- Ponatinib Impurity 19 (CAS CATO-C4X-226919)
- Ponatinib Impurity N72 (CAS 957147-18-1)
- Ponatinib Impurity 34 (CAS CATO-C4X-226934)
- Ponatinib Impurity 16 (CAS CATO-C4X-226916)
Recommended Standards
- Canagliflozin Impurity 95 (CAS 10388-25-7)
- (5E)-5-[(4-tert-Butylphenyl)methylidene]-3-(4-chlorophenyl)-2-sulfanylidene-1,3-thiazolidin-4-one (CAS 882083-07-0)
- 2,6-diiodo-4-methylbenzoic acid (CAS 1048025-56-4)
- 4-Chloro-2-(difluoromethyl)-5-iodopyridine-3-sulfonyl chloride (CAS 1804495-74-6)
- Methylprednisolone Hydrogen Succinate EP Impurity F (CAS 2376134-25-5)
- Canagliflozin Impurity 31 (CAS 2005454-69-1)
- Sildenafil Impurity 243 (CAS 247584-10-7)
- 3-Oxo-3-(2-(trifluoromethoxy)phenyl)propanenitrile (CAS 914636-80-9)
- TERT-BUTYL 1-(1-((BENZYLOXY)CARBONYL) PYRROLIDIN-3-YL)PIPERIDIN-4-YLCARBAMATE (CAS 1823288-48-7)
- 2-Deoxyuridine-5,5-d (CAS 478511-30-7)
- n-[2-(morpholin-4-yl)ethyl]pyridin-2-amine (CAS 67385-33-5)
- 2-(4-Chlorothiophen-2-yl)azetidine (CAS 1526617-77-5)
- 4-Bromo-N-(4-bromophenyl)-N-(4-methoxyphenyl)aniline (CAS 100308-69-8)
- Semaglutide impurity 275 (CAS CATO-C4X-2226275)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com