Upadacitinib Impurity 147 CAS CATO-C4X-2405147
| CAS No. | CATO-C4X-2405147 |
| Molecular Formula | C15H17NO5 |
| Molecular Weight | 291.30 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Upadacitinib Impurity 147 (CAS CATO-C4X-2405147, C15H17NO5) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Upadacitinib Impurity 147 (C15H17NO5) is characterized by a flavonoid core, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Upadacitinib Impurity 147 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C15H17NO5 |
| Molecular Weight | 291.30 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 1 |
Related Upadacitinib Standards
- Upadacitinib Impurity 105 (CAS CATO-C4X-2405105)
- Upadacitinib Impurity 183 (CAS 2500633-42-9)
- Upadacitinib Impurity 74 (CAS 2650489-63-5)
- Upadacitinib Impurity 153 (CAS CATO-C4X-2405153)
- Upadacitinib Impurity 156 (CAS CATO-C4X-2405156)
- Upadacitinib Impurity 157 (CAS CATO-C4X-2405157)
- Upadacitinib Impurity 150 (CAS CATO-C4X-2405150)
- Upadacitinib Impurity 2 (CAS 1201187-46-3)
Recommended Standards
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- Naptalam (CAS 132-66-1)
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- Dotinurad Impurity 28(Triethylamine Salt) (CAS CATO-C4X-2494104)
- Netupitant Impurity 50 (CAS CATO-C4X-122350)
- Erlotinib Impurity 94 (CAS 183320-19-6)
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- (Ser(PO3H2)202,Thr(PO3H2)205)-Tau Peptide (194-213) trifluoroacetate salt (CAS 2022956-55-2)
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