Upadacitinib Impurity 157 CAS CATO-C4X-2405157
| CAS No. | CATO-C4X-2405157 |
| Molecular Formula | C16H19NO4 |
| Molecular Weight | 289.33 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a process- or degradation-related impurity, Upadacitinib Impurity 157 (CAS CATO-C4X-2405157, C16H19NO4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Upadacitinib Impurity 157 (C16H19NO4) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage. The carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C16H19NO4 |
| Molecular Weight | 289.33 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 1 |
Related Upadacitinib Standards
- Upadacitinib Impurity 153 (CAS CATO-C4X-2405153)
- Upadacitinib Impurity 156 (CAS CATO-C4X-2405156)
- Upadacitinib Impurity 150 (CAS CATO-C4X-2405150)
- Upadacitinib Impurity 2 (CAS 1201187-46-3)
- Upadacitinib Impurity 165 (CAS CATO-C4X-2405165)
- Upadacitinib Impurity 147 (CAS CATO-C4X-2405147)
- Upadacitinib Impurity 105 (CAS CATO-C4X-2405105)
- Upadacitinib Impurity 183 (CAS 2500633-42-9)
Recommended Standards
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- Lovastatin Impurity 43 (CAS CATO-C4X-168443)
- Terbutaline Impurity 44 (CAS 2095852-55-2)
- Atorvastatin EP Impurity O (CAS 887196-30-7)
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- 2-(Difluoromethoxy)benzo[d]oxazole-4-carboxaldehyde (CAS 1804191-40-9)
- 2-Amino-n-cycloheptyl-n-methylpentanamide hydrochloride (CAS 1423028-51-6)
- (4-Fluoro-3-(trifluoromethoxy)phenyl)methanol (CAS 86256-18-0)
- N-((2S,3S,4R)-3,4-Dihydroxy-1-(((2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)nonan-2-yl)tetracosanamide (CAS 383187-82-4)
- 14(15) EET (CAS 197508-62-6)
- Neuropeptide Y, porcine (CAS 82785-45-3)
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