Lifitegrast Impurity N68 CAS 89315-56-0
| CAS No. | 89315-56-0 |
| Molecular Formula | C9H9Cl2N |
| Molecular Weight | 202.08 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Lifitegrast Impurity N68 (C9H9Cl2N) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Lifitegrast Impurity N68 (CAS 89315-56-0) is a certified pharmaceutical impurity reference standard with the molecular formula C9H9Cl2N and a molecular weight of 202.08 g/mol.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Lifitegrast Impurity N68 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C9H9Cl2N |
| Molecular Weight | 202.08 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1982 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Lifitegrast Standards
- Lifitegrast Impurity 108 (CAS CATO-C4X-2409108)
- Lifitegrast Impurity 109 (CAS CATO-C4X-2409109)
- Lifitegrast Impurity 149 (CAS CATO-C4X-2409149)
- Lifitegrast Impurity 19 (CAS 1289646-90-7)
- Lifitegrast Impurity N60 (CAS 933752-32-0)
- Lifitegrast Impurity 168 (CAS CATO-C4X-2409168)
- Lifitegrast Impurity 42 (CAS 588703-29-1)
- Lifitegrast Impurity 62 (CAS CATO-C4X-240962)
Recommended Standards
- 5,6-Dichloro-2,3-dihydro-1H-inden-1-amine (CAS 67120-42-7)
- 5,7-Dichloro-1,2,3,4-tetrahydroquinoline (CAS 73253-30-2)
- 5,6-Dichloro-1-methylisoindoline (CAS 2688735-27-3)
- 6,7-Dichloro-1,2,3,4-tetrahydroisoquinoline (CAS 75416-52-3)
- Lamotrigine Impurity 11 (CAS CATO-C4X-167211)
- Tocopherol Impurity 25 (CAS 69371-91-1)
- Brimonidine EP Impurity F (CAS 151110-15-5)
- Methyl 3-amino-2-(pyridin-2-ylmethyl)propanoate (CAS 1038704-50-5)
- 4-Hydroxy-6-(4-methylphenyl)-2,7-diazatricyclo[6.4.0.0,2,6]dodeca-1(12),4,8,10-tetraen-3-one (CAS 938016-20-7)
- N-(3,4-dimethoxybenzyl)-2-methoxyethan-1-amine (CAS 768343-59-5)
- 4-(3-Ethyl-1,2,4-oxadiazol-5-yl)aniline (CAS 1015846-75-9)
- 5,7-Difluoroquinolin-4-amine (CAS 1065092-27-4)
- N-(2-(4-oxo-4H-benzo[d][1,3]oxazin-2-yl)phenyl)naphthalene-2-sulfonamide (CAS 10128-55-9)
- Hexapeptide-1 (CAS CATO-CPTD788821)
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