Lifitegrast Impurity 166 CAS CATO-C4X-2409166
| CAS No. | CATO-C4X-2409166 |
| Molecular Formula | C18H16Br2N2O2 |
| Molecular Weight | 452.14 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
CATO supplies Lifitegrast Impurity 166 (CAS CATO-C4X-2409166), a pharmacopoeial impurity reference standard (molecular formula C18H16Br2N2O2, MW 452.14 g/mol) used for the identification and quantification of trace impurities in APIs.
Based on its molecular formula C18H16Br2N2O2, Lifitegrast Impurity 166 contains a steroid core, an amide group, a hydroxyl group, an ether linkage, bromine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 452.14 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C18H16Br2N2O2 |
| Molecular Weight | 452.14 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | ≥95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 2 |
Related Lifitegrast Standards
- Lifitegrast Impurity 13 (CAS CATO-C4X-240913)
- Lifitegrast Impurity 135 (CAS CATO-C4X-2409135)
- Lifitegrast Impurity 45 (CAS CATO-C4X-240945)
- Lifitegrast Impurity 100 (CAS CATO-C4X-2409100)
- Lifitegrast Impurity 65 (CAS 2637374-15-1)
- Lifitegrast Impurity 9 (CAS 1289646-72-5)
- Lifitegrast Impurity 44 (CAS CATO-C4X-240944)
- Lifitegrast Impurity 46 (CAS CATO-C4X-240946)
Recommended Standards
- Lithium ((2S,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)methyl triphosphate (CAS 84445-38-5)
- Methyl 7-bromo-8-(cyclopent-1-en-1-yl)-2-oxo-2H-selenopheno[3,2-h]chromene-3-carboxylate (CAS 2173398-08-6)
- 1-Chloro-3,5-dimethoxy-2-nitrobenzene (CAS 90-25-5)
- 2-((3-Bromophenyl)(5-chloro-2-methoxyphenyl) methyl)-4-chloro-1-methoxybenzene (CAS 1011800-53-5)
- Donepezil EP impurity G HCl (CAS 2452407-72-4（free base）)
- Finerenone Impurity 136 (CAS CATO-C4X-2880136)
- Dacomitinib Impurity 26 (CAS CATO-C4X-208626)
- Argatroban Impurity 25 (CAS CATO-C4X-100725)
- 2-[2-(2,4-Dichloro-phenyl)-ethyl]-6-hydroxy-benzoic acid methyl ester (CAS 1171924-81-4)
- Benzyl azetidine-3-carboxylate (CAS 405513-07-7)
- 4-Nitro-N-(2-oxotetrahydrofuran-3-yl)benzamide (CAS 61315-65-9)
- Triarylsulfonium hexafluoroantimonate mixture (CAS 109037-75-4)
- Benzyl (rel-4-(4-acetylphenyl)cyclohexyl)carbamate (CAS 2582720-91-8)
- [a-Glu](Side chain transposition)- Semaglutide (CAS CATO-C4X-2226111)
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