Lifitegrast Impurity 54 CAS CATO-C4X-240954
| CAS No. | CATO-C4X-240954 |
| Molecular Formula | C22H22Cl2N2O6S |
| Molecular Weight | 513.39 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 513.39 g/mol gives Lifitegrast Impurity 54 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Lifitegrast Impurity 54 (CAS CATO-C4X-240954, C22H22Cl2N2O6S) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Lifitegrast Impurity 54 (C22H22Cl2N2O6S) contains a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Lifitegrast Impurity 54 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C22H22Cl2N2O6S |
| Molecular Weight | 513.39 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
Related Lifitegrast Standards
- Lifitegrast Impurity 75 (CAS CATO-C4X-240975)
- Lifitegrast Impurity 115 (CAS CATO-C4X-2409115)
- Lifitegrast Impurity 131 (CAS CATO-C4X-2409131)
- Lifitegrast Impurity 43 (CAS CATO-C4X-240943)
- Lifitegrast Impurity 60 (CAS CATO-C4X-240960)
- Lifitegrast Impurity 68 (CAS CATO-C4X-240968)
- Lifitegrast Impurity 48 (CAS CATO-C4X-240948)
- Lifitegrast Impurity 37 (CAS 1194550-56-5)
Recommended Standards
- 9α-Bromo Flunisolide (CAS CATO-C4X-16483)
- (4S,4′S)-2,2′-(5,5′-Dichloro[1,1′-biphenyl]-2,2′-diyl)bis[4,5-dihydro-4-phenyloxazole] (CAS 944133-16-8)
- 9-Bromo-6α-fluoro-11β,17,21-trihydroxy-16α-methyl-pregna-1,4-diene-3,20-dione 21-Acetate (CAS 1997-73-5)
- 3-(1H-indol-6-yl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridine (CAS 1112948-62-5)
- Mizolastine Impurity 2 (CAS 935860-13-2)
- Rufloxacin Impurity 1 (CAS CATO-C4X-29421)
- Ketoprofen Impurity 98 (CAS CATO-C4X-147198)
- 3-[(2S,3R)-1-(4-Chlorophenyl)-3-hydroxy-2-butyl]benzonitrile (CAS 941280-53-1)
- 3-Bromo-4-[(4-chlorobenzyl)oxy]-5-methoxybenzaldehyde (CAS 345983-02-0)
- 2-Benzyl-2,8-diazaspiro[5.5]undecane (CAS 401648-35-9)
- 3-Morpholin-4-ylbutan-1-amine (CAS 776329-10-3)
- 2-Pyridinamine,5-methyl-,1-oxide (CAS 66362-95-6)
- 2-{[(2-chlorophenyl)methyl]amino}propan-1-ol (CAS 1118787-00-0)
- Palmitoyl Tripeptide-1 HCl (CAS 2757690-14-3)
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