Lifitegrast Impurity 115 CAS CATO-C4X-2409115
| CAS No. | CATO-C4X-2409115 |
| Molecular Formula | C25H16Cl2N4O4 |
| Molecular Weight | 507.32 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Lifitegrast Impurity 115.
As a process- or degradation-related impurity, Lifitegrast Impurity 115 (CAS CATO-C4X-2409115, C25H16Cl2N4O4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution, Lifitegrast Impurity 115 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 507.32 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Lifitegrast Impurity 115 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C25H16Cl2N4O4 |
| Molecular Weight | 507.32 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 19.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 4 |
Related Lifitegrast Standards
- Lifitegrast Impurity 75 (CAS CATO-C4X-240975)
- Lifitegrast Impurity 131 (CAS CATO-C4X-2409131)
- Lifitegrast Impurity 43 (CAS CATO-C4X-240943)
- Lifitegrast Impurity 54 (CAS CATO-C4X-240954)
- Lifitegrast Impurity 60 (CAS CATO-C4X-240960)
- Lifitegrast Impurity 68 (CAS CATO-C4X-240968)
- Lifitegrast Impurity 37 (CAS 1194550-56-5)
- Lifitegrast Impurity 170 (CAS CATO-C4X-2409170)
Recommended Standards
- 5-({[3-chloro-5-(trifluoromethyl)pyridin-2-yl]amino}methyl)-N-{[(4-chlorophenyl)carbamothioyl]amino}-4,5-dihydro-1,2-oxazole-3-carboxamide (CAS 338399-35-2)
- ((3AS,4R,6R,6aR)-6-(6-amino-9H-purin-9-yl)-2-phenyltetrahydrofuro[3,4-d][1,3,2]dioxaborol-4-yl)methyl 4-methylbenzenesulfonate (CAS 23312-76-7)
- 2-[1-(3,4-Dichlorophenyl)-5-methyl-1H-1,2,3-triazole-4-carbonyl]-3-(4-methoxyphenyl)-5-(trifluoromethyl)pyridine (CAS 882748-03-0)
- (E)-4-(benzo[d][1,3]dioxol-5-yl)-2-(3-bromostyryl)-5-oxo-5H-indeno[1,2-b]pyridine-3-carbonitrile (CAS 866142-81-6)
- Daclatasvir Impurity 31 (CAS 2698401-11-3)
- Lysine Impurity 40 (CAS CATO-C4X-221140)
- Nintedanib Impurity 84 (CAS 2770008-35-8)
- 2,6-Dimethoxy-5-methylpyridine-3-methanol (CAS 1879026-22-8)
- tert-Butyl (1R*,4R*)-4-(tetrahydro-2H-pyran-4-carbonylamino)cyclohexylcarbamate (CAS 1286264-11-6)
- Daunomycinone-d3 (CAS 1217860-39-3)
- 4,5-Dimethyl-6-nitro-N1-(pentan-3-yl)benzene-1,2-diamine (CAS 66382-22-7)
- trans-(E)-Flupentixol DiHCl (CAS 51529-02-3)
- 4-(2,3-Dimethylphenoxy)-3-(trifluoromethyl)aniline (CAS 946697-55-8)
- Semaglutide impurity 215 (CAS CATO-C4X-2226215)
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