Lifitegrast Impurity 131 CAS CATO-C4X-2409131
| CAS No. | CATO-C4X-2409131 |
| Molecular Formula | C20H15Cl4N3O4 |
| Molecular Weight | 503.16 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Lifitegrast Impurity 131 (CAS CATO-C4X-2409131) is a certified pharmaceutical impurity reference standard with the molecular formula C20H15Cl4N3O4 and a molecular weight of 503.16 g/mol.
Based on its molecular formula C20H15Cl4N3O4, Lifitegrast Impurity 131 contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 503.16 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C20H15Cl4N3O4 |
| Molecular Weight | 503.16 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | ≥95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Lifitegrast Standards
- Lifitegrast Impurity 43 (CAS CATO-C4X-240943)
- Lifitegrast Impurity 60 (CAS CATO-C4X-240960)
- Lifitegrast Impurity 68 (CAS CATO-C4X-240968)
- Lifitegrast Impurity 115 (CAS CATO-C4X-2409115)
- Lifitegrast Impurity 75 (CAS CATO-C4X-240975)
- Lifitegrast Impurity 54 (CAS CATO-C4X-240954)
- Lifitegrast Impurity 37 (CAS 1194550-56-5)
- Lifitegrast Impurity 170 (CAS CATO-C4X-2409170)
Recommended Standards
- 11-Azido-1,1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8-heptadecafluoroundecane (CAS 852527-61-8)
- Dotinurad Impurity 148 (CAS CATO-C4X-2494148)
- (3,5-Bis(trifluoromethyl)phenyl)tributylstannane (CAS 717918-62-2)
- 6,8-Dibromo-2-(4-(phenylsulfonyl)phenyl)quinoline (CAS 861210-54-0)
- Ilaprazole Impurity 210 (CAS CATO-C4X-1130210)
- Tadalafil EP Impurity F (CAS 2747958-44-5)
- Sorafenib Impurity 10 (CAS 2004659-85-0)
- Ethyl 6-(chloromethyl)-4-(4-fluorophenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate (CAS 1260906-12-4)
- 5-(Acetamidomethyl)-2-methylfuran-3-carboxylic acid (CAS 1178353-98-4)
- 2-(6-Fluoro-5-phenylpyridin-2-yl)acetic acid (CAS 1227579-75-0)
- 5-ethynylpyridine-2-carbaldehyde (CAS 940911-03-5)
- Methyl 2-(4-benzyl-3,4-dihydro-2H-benzo[b][1,4]oxazin-3-yl)acetate (CAS 861212-96-6)
- Ethyl 2-{4-[5-(4-chlorophenyl)-1H-pyrazol-3-yl]piperidino}acetate (CAS 321848-30-0)
- Semaglutide (CAS 910463-68-2（free base）)
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