Venetoclax Impurity 134 CAS CATO-C4X-2495134
| CAS No. | CATO-C4X-2495134 |
| Molecular Formula | C47H43ClN6O6 |
| Molecular Weight | 823.33 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 823.33 g/mol gives Venetoclax Impurity 134 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Venetoclax Impurity 134 (CAS CATO-C4X-2495134, C47H43ClN6O6) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Venetoclax Impurity 134 (C47H43ClN6O6) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C47H43ClN6O6 |
| Molecular Weight | 823.33 g/mol |
| Purity | ≥95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 29.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 6 |
Related Venetoclax Standards
- Venetoclax Impurity 112 (CAS CATO-C4X-2495112)
- Venetoclax Impurity 8 (CAS 2573767-91-4)
- Venetoclax Impurity 100 (CAS CATO-C4X-2495100)
- Venetoclax Impurity 121 (CAS CATO-C4X-2495121)
- Venetoclax Impurity 42 (CAS CATO-C4X-249542)
- Venetoclax Impurity 64 (CAS CATO-C4X-249564)
- Venetoclax Impurity 33 (CAS CATO-C4X-249533)
- Venetoclax Impurity 48 (CAS CATO-C4X-249548)
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- 3,4-Dimethyl-3,4-dihydro-2H-benzo[b][1,4]oxazine (CAS 76213-68-8)
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