Venetoclax Impurity 61 CAS CATO-C4X-249561
| CAS No. | CATO-C4X-249561 |
| Molecular Formula | C46H50ClN7O8S |
| Molecular Weight | 896.45 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a process- or degradation-related impurity, Venetoclax Impurity 61 (CAS CATO-C4X-249561, C46H50ClN7O8S) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Venetoclax Impurity 61 (C46H50ClN7O8S) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C46H50ClN7O8S |
| Molecular Weight | 896.45 g/mol |
| Purity | ≥95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 25.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 7 |
| Sulfur Atoms | 1 |
Related Venetoclax Standards
- Venetoclax Nitroso Impurity 15 (CAS CATO-C4X-249515)
- Venetoclax Impurity 24 (CAS CATO-C4X-249524)
- Venetoclax Impurity 50 (CAS CATO-C4X-249550)
- Venetoclax Impurity 60 (CAS CATO-C4X-249560)
- Venetoclax Impurity 32 (CAS CATO-C4X-249532)
- Venetoclax Impuritry 7 (CAS 2469279-00-1)
- Venetoclax Impurity 47 (CAS CATO-C4X-249547)
- Venetoclax Impurity 13 (CAS CATO-C4X-249513)
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