Gefapixant Impurity 3 CAS CATO-C4X-28493
| CAS No. | CATO-C4X-28493 |
| Molecular Formula | C13H16BrN5O3S |
| Molecular Weight | 402.27 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Gefapixant Impurity 3 (CAS CATO-C4X-28493, C13H16BrN5O3S) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Gefapixant Impurity 3 (C13H16BrN5O3S) contains a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, bromine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Gefapixant Impurity 3 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C13H16BrN5O3S |
| Molecular Weight | 402.27 g/mol |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 5 |
| Sulfur Atoms | 1 |
Related Gefapixant Standards
Recommended Standards
- Phloroglucinol impurity 60 (CAS CATO-C4X-221760)
- 1-Piperidinecarboxylic acid, 4-(4-bromobenzoyl)-, phenylmethyl ester (CAS 1416908-65-0)
- Erlotinib Impurity 3 (CAS 183321-82-6)
- (S)-3-(4-(3-bromopropoxy)phenyl)-2-((tert-butoxycarbonyl)amino)propanoic acid (CAS 1579942-10-1)
- Bromhexine Impurity 11 (CAS 21237-84-3)
- Vardenafil Impurity N1 (CAS 448184-56-3)
- Apremilast Impurity 79 (CAS 608141-42-0)
- 3-(4-Chlorophenyl)-5-[(tetrahydro-2H-pyran-2-yloxy)methyl]isoxazole-4-carboxylic acid (CAS 1242926-34-6)
- Valproate Impurity 77 (CAS CATO-C4X-116677)
- tert-Butyl 2-bromo-5H-pyrrolo[3,4-b]pyridine-6(7H)-carboxylate (CAS 1375302-76-3)
- Hydroxy-Dynasore (CAS 1256493-34-1)
- Methyl 2-amino-4-(3-methoxyphenyl)pyrimidine-5-carboxylate (CAS 1187385-80-3)
- 8-Bromoquinoline-2-carbaldehyde (CAS 904886-25-5)
- Tirzepatide Impurity 17 (CAS CATO-C4X-324017)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com