Tafamidis Impurity 12 CAS CATO-C4X-287712
| CAS No. | CATO-C4X-287712 |
| Molecular Formula | C22H13Cl4NO5 |
| Molecular Weight | 513.15 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Tafamidis Impurity 12 (CAS CATO-C4X-287712, C22H13Cl4NO5) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution, Tafamidis Impurity 12 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 513.15 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Tafamidis Impurity 12 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C22H13Cl4NO5 |
| Molecular Weight | 513.15 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Tafamidis Standards
- Tafamidis Impurity 2 (CAS CATO-C4X-28772)
- Tafamidis Impurity 5 (CAS CATO-C4X-28775)
- Tafamidis Impurity 7 (CAS CATO-C4X-28777)
- Tafamidis Impurity 13 (CAS CATO-C4X-287713)
- Tafamidis Impurity 1 (CAS 1184581-58-5)
- Tafamidis Impurity 3 (CAS 1183404-30-9)
- Tafamidis Impurity 9 (CAS 1395964-06-3)
- Tafamidis (CAS 594839-88-0)
Recommended Standards
- 2,2,3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-nonadecafluorodecanamide 307-40-4 Perfluorodecanamide (CAS 307-40-4)
- N-(2,6-Dibromo-4-fluorophenyl)-1-(diphenylphosphoryl)methanethioamide (CAS 680213-13-2)
- FR-651A (CAS 87-84-3)
- N-Methylperfluorooctanesulfonamide (CAS 31506-32-8)
- Revefenacin impurity 95 (CAS CATO-C4X-203195)
- Ifosfamide Impurity 4 (CAS CATO-C4X-20014)
- Landiolol Impurity 12 (CAS 2180628-04-8)
- Cefazolin 3-Hydroxymethyl Impurity Sodium Salt (CAS 50971-65-8)
- 5-[(tert-Butoxy)carbonyl]-4H,5H,6H,7H-thieno[3,2-c]pyridine-4-carboxylic acid (CAS 1291217-74-7)
- 6-Nitrobenzo[a]pyrene-d11 (CAS 352431-12-0)
- Methyl 5-(fluorosulfonyl)-2-hydroxybenzoate (CAS 400-89-5)
- 3-{[(quinolin-8-yl)amino]methyl}phenol (CAS 1019573-28-4)
- tert-Butyl ((1-(2-chloro-6-methylpyrimidin-4-yl)piperidin-2-yl)methyl)carbamate (CAS 1261234-49-4)
- Peptide 437 (CAS CATO-CPTD788437)
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