Vericiguat impurity 47 CAS CATO-C4X-289647
| CAS No. | CATO-C4X-289647 |
| Molecular Formula | C19H17FN8O2 |
| Molecular Weight | 408.39 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a process- or degradation-related impurity, Vericiguat impurity 47 (CAS CATO-C4X-289647, C19H17FN8O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Vericiguat impurity 47 (C19H17FN8O2) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 15.0, corresponding to approximately 15 ring(s) or double-bond equivalent(s). With a molecular weight of 408.39 g/mol, it falls into the moderately-high-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C19H17FN8O2 |
| Molecular Weight | 408.39 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 8 |
Related Vericiguat Standards
- Vericiguat Impurity 100 (CAS 1011527-86-8)
- Vericiguat Impurity 3 (CAS 3052969-91-9)
- Vericiguat impurity 53 (CAS CATO-C4X-289653)
- Vericiguat Impurity 62 (CAS CATO-C4X-289662)
- Vericiguat Impurity 67 (CAS 2755814-39-0)
- Vericiguat Impurity 77 (CAS CATO-C4X-289677)
- Vericiguat Impurity 17 (CAS 625115-49-3)
- Vericiguat Impurity 4 (CAS CATO-C4X-28964)
Recommended Standards
- 6,8-Difluoro-1,4-dihydro-1-(N-methylformamido)-7-(4-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic Acid Ethyl Ester (CAS 158585-86-5)
- Dibenzo[b,d]furan-4,6-diyl dibenzoate (CAS 1964440-20-7)
- Riociguat EP Impurity A (CAS 625115-52-8)
- (4S)-4-Ethyl-4-hydroxy-12-(2-hydroxyethoxy)-1,12-dihydro-14H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H)-dione (CAS 200619-13-2)
- Nintedanib Impurity 71 (CAS 2243384-71-4)
- Famotidine Impurity 25 (CAS 69014-12-6)
- Roxadustat Impurity 144 (CAS CATO-C4X-2213144)
- Gc-6506-wettable powder granules (CAS 3254-63-5)
- Pemetrexed Impurity 19 (CAS CATO-C4X-172619)
- Methyl 2-hydroxybenzimidate (CAS 26384-76-9)
- 5-(Difluoromethyl)-2-fluoro-3-nitropyridin-4-amine (CAS 1805062-32-1)
- N-hexyltetrahydro-2H-thiopyran-4-amine (CAS 1153794-02-5)
- 6-(Difluoromethyl)indoline-2,3-dione (CAS 1344904-59-1)
- Cycloaspeptide A (CAS 109171-13-3)
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