Vericiguat impurity 52 CAS CATO-C4X-289652
| CAS No. | CATO-C4X-289652 |
| Molecular Formula | C19H16F2N8O2 |
| Molecular Weight | 426.38 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Vericiguat impurity 52 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Vericiguat impurity 52 (CAS CATO-C4X-289652) is a certified pharmaceutical impurity reference standard with the molecular formula C19H16F2N8O2 and a molecular weight of 426.38 g/mol.
Structurally, Vericiguat impurity 52 (C19H16F2N8O2) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 15.0, corresponding to approximately 15 ring(s) or double-bond equivalent(s). With a molecular weight of 426.38 g/mol, it falls into the moderately-high-molecular-weight range. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C19H16F2N8O2 |
| Molecular Weight | 426.38 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 8 |
Related Vericiguat Standards
- Vericiguat (CAS 1350653-20-1)
- Vericiguat Impurity 101 (CAS 1374344-58-7)
- Vericiguat Impurity 37 (CAS CATO-C4X-289637)
- Vericiguat Impurity 38 (CAS CATO-C4X-289638)
- Vericiguat Impurity 88 (CAS CATO-C4X-289688)
- Vericiguat Impurity 17 (CAS 625115-49-3)
- Vericiguat Impurity 77 (CAS CATO-C4X-289677)
- Vericiguat Impurity 78 (CAS CATO-C4X-289678)
Recommended Standards
- (5Z)-5-({3-[2-nitro-4-(trifluoromethyl)phenoxy]phenyl}methylidene)-2-sulfanylidene-1,3-thiazolidin-4-one (CAS 1055978-70-5)
- N-(1-(2,2-Difluoro-2-(4-(trifluoromethyl)phenyl)ethyl)-piperidin-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine (CAS 913574-42-2)
- Fluacrypyrim (CAS 229977-93-9)
- Uridine Impurity 12 (CAS 146426-20-2)
- Baloxavir Marboxil Impurity 221 (CAS CATO-C4X-2108221)
- Valsartan Impurity 125 (CAS 1894176-40-9)
- Dolutegravir Impurity 8 (CAS 1863916-88-4)
- L-Erythrulose (CAS 533-50-6)
- Ilaprazole Impurity 220 (CAS CATO-C4X-1130220)
- tert-Butyl 3-chloro-5H-pyrrolo[2,3-c]pyridazine-7(6H)-carboxylate (CAS 2032381-90-9)
- 1040692-77-0 3-{[3-(Ethylamino)propyl]amino}-1-propanol 7934AC C8H20N2O (CAS 1040692-77-0)
- 2-(3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)propan-2-amine (CAS 1075683-56-5)
- (1R,2S)-2-(benzylamino)cyclohexan-1-ol (CAS 882409-12-3)
- (D-Ala2)-Gastric Inhibitory Polypeptide (human) trifluoroacetate salt (CAS 444073-04-5)
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