Resmetirom Impurity 102 CAS CATO-C4X-2912102
| CAS No. | CATO-C4X-2912102 |
| Molecular Formula | C12H10Cl3N3O2 |
| Molecular Weight | 334.59 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Resmetirom Impurity 102 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
CATO supplies Resmetirom Impurity 102 (CAS CATO-C4X-2912102), a pharmacopoeial impurity reference standard (molecular formula C12H10Cl3N3O2, MW 334.59 g/mol) used for the identification and quantification of trace impurities in APIs.
Resmetirom Impurity 102 (C12H10Cl3N3O2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C12H10Cl3N3O2 |
| Molecular Weight | 334.59 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Resmetirom Standards
- Resmetirom Impurity 48 (CAS CATO-C4X-291248)
- Resmetirom impurity 103 (CAS CATO-C4X-2912103)
- Resmetirom Impurity 30 (CAS CATO-C4X-291230)
- Resmetirom Impurity 5 (CAS 920509-27-9)
- Resmetirom impurity 68 (CAS CATO-C4X-291268)
- Resmetirom impurity 69 (CAS CATO-C4X-291269)
- Resmetirom Impurity 50 (CAS CATO-C4X-291250)
- Resmetirom impurity 108 (CAS CATO-C4X-2912108)
Recommended Standards
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- 1217842-35-7 1333AD C12H13BrClNO3 Methyl (2S,4S)-4-(2-bromo-4-chlorophenoxy)-2-pyrrolidinecarboxylate (CAS 1217842-35-7)
- 3-(4-Bromophenyl)-5-(3-chlorophenyl)isoxazole (CAS 651021-75-9)
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- MW-150 hydrochloride, >98% (HPLC) (CAS 1923773-01-6)
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- 3-bromo-L-Tyrosine (CAS 38739-13-8)
- 3-Chloro-4-(difluoromethoxy)benzimidamide (CAS 1250558-67-8)
- N-Methylcyclohexanecarboxamide (CAS 6830-84-8)
- Tirzepatide Impurity 61 (CAS CATO-C4X-324061)
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