Resmetirom Impurity 35 CAS CATO-C4X-291235
| CAS No. | CATO-C4X-291235 |
| Molecular Formula | C22H24Cl2N6O5 |
| Molecular Weight | 523.37 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO manufactures Resmetirom Impurity 35 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
CATO supplies Resmetirom Impurity 35 (CAS CATO-C4X-291235), a pharmacopoeial impurity reference standard (molecular formula C22H24Cl2N6O5, MW 523.37 g/mol) used for the identification and quantification of trace impurities in APIs.
Resmetirom Impurity 35 (C22H24Cl2N6O5) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C22H24Cl2N6O5 |
| Molecular Weight | 523.37 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 6 |
Related Resmetirom Standards
- Resmetirom impurity 57 (CAS 2768217-11-2)
- Resmetirom impurity 115 (CAS CATO-C4X-2912115)
- Resmetirom Impurity 49 (CAS CATO-C4X-291249)
- Resmetirom impurity 60 (CAS 2403724-53-6)
- Resmetirom impurity 89 (CAS CATO-C4X-291289)
- Resmetirom Impurity 38 (CAS CATO-C4X-291238)
- Resmetirom impurity 113 (CAS CATO-C4X-2912113)
- Resmetirom impurity 85 (CAS CATO-C4X-291285)
Recommended Standards
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- Osimertinib Impurity 75 (CAS CATO-C4X-204575)
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- Isavuconazole Impurity 139 (CAS CATO-C4X-1236139)
- Ethyl 1-cyano-2-methylpyrrolo[2,1-a]isoquinoline-3-carboxylate (CAS 618070-05-6)
- 4-fluoro-2-methyl-1H-indol-5-amine (CAS 398487-76-8)
- (1-(2,2-Difluorobenzo[d][1,3]dioxol-5-yl)cyclopropyl)methanamine (CAS 1500197-38-5)
- 2-Oxo-2-(2-phenylindolizin-3-yl)acetyl chloride (CAS 101081-39-4)
- 3-Methoxy-3-methylbut-1-yne (CAS 13994-57-5)
- 1-((1-Ethyl-1h-pyrazol-4-yl)methyl)cyclopropane-1-carboxylic acid (CAS 1489897-06-4)
- (Glu9)-Exenatide (2-39) trifluoroacetate salt (CAS 196109-34-9)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com