Resmetirom impurity 113 CAS CATO-C4X-2912113
| CAS No. | CATO-C4X-2912113 |
| Molecular Formula | C19H18Cl2N6O6 |
| Molecular Weight | 497.29 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Resmetirom impurity 113 is closely related to a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
CATO supplies Resmetirom impurity 113 (CAS CATO-C4X-2912113), a pharmacopoeial impurity reference standard (molecular formula C19H18Cl2N6O6, MW 497.29 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Resmetirom impurity 113 (C19H18Cl2N6O6) is characterized by a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Resmetirom impurity 113 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C19H18Cl2N6O6 |
| Molecular Weight | 497.29 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 6 |
Related Resmetirom Standards
- Resmetirom impurity 85 (CAS CATO-C4X-291285)
- Resmetirom Impurity 38 (CAS CATO-C4X-291238)
- Resmetirom impurity 60 (CAS 2403724-53-6)
- Resmetirom impurity 89 (CAS CATO-C4X-291289)
- Resmetirom Impurity 49 (CAS CATO-C4X-291249)
- Resmetirom impurity 110 (CAS CATO-C4X-2912110)
- Resmetirom impurity 120 (CAS CATO-C4X-2912120)
- Resmetirom impurity 125 (CAS CATO-C4X-2912125)
Recommended Standards
- N-[2-(2,6-dioxo-3-piperidyl)-1,3-dioxo-isoindolin-4-yl]-6-iodo-hexanamide (CAS 2349356-03-0)
- Ethyl 1-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-4-(4-chlorophenyl)-6-methyl-4,7-dihydro-1H-pyrazolo[3,4-b]pyridine-5-carboxylate (CAS 339100-78-6)
- Ethyl 4-(2-(2-ethoxy-4-formyl-6-iodophenoxy)acetamido)benzoate (CAS 832677-97-1)
- 1-(1-(3,5-Bis(trifluoromethyl)phenyl)-1H-1,2,3-triazol-4-yl)-2-(3-(trifluoromethyl)phenoxy)propan-1-one (CAS 477847-95-3)
- Cinacalcet Impurity N86 (CAS 129254-76-8)
- Selegiline Impurity 5 (CAS CATO-C4X-19165)
- Pomalidomide Impurity 55 (CAS CATO-C4X-135455)
- 7,8-Dichloro-4-methyl-1,2,3,4-tetrahydroquinoline (CAS 1706464-58-5)
- 1-(((6-Methylpyridin-3-yl)oxy)methyl)cyclopropanamine (CAS 959957-86-9)
- 3-amino-2-phenylpyridine-4-carboxylic acid (CAS 1547501-48-3)
- 4-(tert-Butyl)-2-chloro-6-methylphenol (CAS 86445-78-5)
- Bisphenol A Bis(4-maleimidophenyl Ether) (CAS 79922-55-7)
- H-Met-D-Met-OH (CAS 89680-18-2)
- [Tyr15] Fibrinopeptide B, human (CAS 125455-56-3)
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