Resmetirom impurity 57 CAS 2768217-11-2
| CAS No. | 2768217-11-2 |
| Molecular Formula | C19H12Cl4N4O6 |
| Molecular Weight | 534.13 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Resmetirom impurity 57 is closely related to a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
As a process- or degradation-related impurity, Resmetirom impurity 57 (CAS 2768217-11-2, C19H12Cl4N4O6) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Resmetirom impurity 57 (C19H12Cl4N4O6) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 14.0, corresponding to approximately 14 ring(s) or double-bond equivalent(s). With a molecular weight of 534.13 g/mol, it falls into the moderately-high-molecular-weight range. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Resmetirom impurity 57 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C19H12Cl4N4O6 |
| Molecular Weight | 534.13 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2003 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 4 |
Related Resmetirom Standards
- Resmetirom impurity 115 (CAS CATO-C4X-2912115)
- Resmetirom Impurity 35 (CAS CATO-C4X-291235)
- Resmetirom Impurity 49 (CAS CATO-C4X-291249)
- Resmetirom impurity 60 (CAS 2403724-53-6)
- Resmetirom impurity 89 (CAS CATO-C4X-291289)
- Resmetirom Impurity 38 (CAS CATO-C4X-291238)
- Resmetirom impurity 113 (CAS CATO-C4X-2912113)
- Resmetirom impurity 85 (CAS CATO-C4X-291285)
Recommended Standards
- Pyronaridine Impurity 4 (CAS CATO-C4X-29784)
- Hydrazinecarbothioamide, 2,2'-(1,2-ethanediylidene)bis[N-[(4-ethoxyphenyl)methyl]-, copper complex (CAS 123988-73-8)
- 3,4,5-Tris(4-bromophenyl)-4H-1,2,4-triazole (CAS 920984-66-3)
- N1,N1-Bis(4,6-dichloro-2-phenylpyrimidin-5-yl)oxalamide (CAS 59808-58-1)
- Ezetimibe Impurity 140 (CAS CATO-C4X-1098140)
- Ursodeoxycholic Acid Impurity 131 (CAS CATO-C4X-1422131)
- Lumateperone Impurity 74 Tosylate (CAS CATO-C4X-220174)
- (S)-2-Amino-3-(4-vinylphenyl)propanoic acid hydrochloride (CAS 1810074-65-7)
- N-(2-Methoxyphenyl)-2-methylbenzenesulfonamide (CAS 160878-35-3)
- n-(3-Methyl-1-phenylbutyl)isobutyramide (CAS 1197635-84-9)
- 2-Methoxy-N-(4-phenylcyclohexyl)acetamide (CAS 1241173-33-0)
- tert-Butyl 2-methylaziridine-1-carboxylate (CAS 129319-71-7)
- (S)-1-(4-Bromo-3-fluorophenyl)ethanamine hydrochloride (CAS 2109874-10-2)
- Des-Gln24-Tirzepatide (CAS CATO-CPTD788949)
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