Resmetirom impurity 89 CAS CATO-C4X-291289
| CAS No. | CATO-C4X-291289 |
| Molecular Formula | C19H17Cl3N6O4 |
| Molecular Weight | 499.74 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Resmetirom impurity 89.
Resmetirom impurity 89 (CAS CATO-C4X-291289) is a certified pharmaceutical impurity reference standard with the molecular formula C19H17Cl3N6O4 and a molecular weight of 499.74 g/mol.
The molecular framework of Resmetirom impurity 89 (C19H17Cl3N6O4) is characterized by a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Resmetirom impurity 89 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C19H17Cl3N6O4 |
| Molecular Weight | 499.74 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 6 |
Related Resmetirom Standards
- Resmetirom impurity 60 (CAS 2403724-53-6)
- Resmetirom Impurity 38 (CAS CATO-C4X-291238)
- Resmetirom Impurity 49 (CAS CATO-C4X-291249)
- Resmetirom impurity 113 (CAS CATO-C4X-2912113)
- Resmetirom impurity 85 (CAS CATO-C4X-291285)
- Resmetirom impurity 110 (CAS CATO-C4X-2912110)
- Resmetirom impurity 120 (CAS CATO-C4X-2912120)
- Resmetirom impurity 125 (CAS CATO-C4X-2912125)
Recommended Standards
- 4-amino-1-[(2R,4S,5R)-4-[tert-butyl(dimethyl)silyl]oxy-5-[[tert-butyl(dimethyl)silyl]oxymethyl]tetrahydrofuran-2-yl]-2-oxo-pyrimidine-5-carboxylic acid (CAS 1630012-78-0)
- 3-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-1-(2-(2,4-dichlorophenoxy)ethyl)-2-methyl-1H-indole (CAS 400074-07-9)
- 1-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-4-(2,6-dinitro-4-(trifluoromethyl)phenyl)piperazine (CAS 338979-22-9)
- (Z)-[(4-Bromophenyl)[2-(4-chlorophenyl)cyclopropyl]methylidene]amino 3-nitrobenzoate (CAS 338415-76-2)
- Lornoxicam Impurity 45 (CAS CATO-C4X-201645)
- Meldonium EP Impurity C (CAS 59514-00-0)
- Cefadroxil Sulfoxide(RS) (CAS 182290-77-3)
- 2-Phenylacrylonitrile (CAS 495-10-3)
- 1-(1-(3-(Trifluoromethyl)phenyl)-1H-1,2,4-triazol-3-yl)propan-2-one (CAS 1346809-34-4)
- H-Cys(aminoethyl)-OH · HCl (CAS 4099-35-8)
- 2-{2,9-dioxaspiro[5.5]undecan-3-yl}acetic acid (CAS 2090711-64-9)
- 2,4,6-Triiodobenzenesulfonamide (CAS 1099632-52-6)
- 5H,6H,7H-cyclopenta[c]pyridin-5-one (CAS 350847-80-2)
- Peptide Impurity 09 X TFA Salt (CAS CATO-CPTD788809)
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