Abemaciclib impurity 121 CAS CATO-C4X-2937121
| CAS No. | CATO-C4X-2937121 |
| Molecular Formula | C32H43FN8O |
| Molecular Weight | 574.74 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
As a process- or degradation-related impurity, Abemaciclib impurity 121 (CAS CATO-C4X-2937121, C32H43FN8O) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Abemaciclib impurity 121 (C32H43FN8O) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 15.0, corresponding to approximately 15 ring(s) or double-bond equivalent(s). With a molecular weight of 574.74 g/mol, it falls into the moderately-high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C32H43FN8O |
| Molecular Weight | 574.74 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 8 |
Related Abemaciclib Standards
- Abemaciclib Impurity 90 (CAS CATO-C4X-293790)
- Abemaciclib Impurity 179 (CAS CATO-C4X-2937179)
- Abemaciclib Impurity 19 (CAS CATO-C4X-293719)
- Abemaciclib Impurity 74 (CAS CATO-C4X-293774)
- Abemaciclib Impurity 58 (CAS CATO-C4X-293758)
- Abemaciclib Impurity 150 (CAS CATO-C4X-2937150)
- Abemaciclib Impurity 190 (CAS CATO-C4X-2937190)
- Abemaciclib Impurity 143 (CAS CATO-C4X-2937143)
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