Abemaciclib Impurity 14 CAS CATO-C4X-293714
| CAS No. | CATO-C4X-293714 |
| Molecular Formula | C27H32F2N8 |
| Molecular Weight | 506.59 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Abemaciclib Impurity 14 (CAS CATO-C4X-293714, C27H32F2N8) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Abemaciclib Impurity 14 (C27H32F2N8) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine substitution. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C27H32F2N8 |
| Molecular Weight | 506.59 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 8 |
Related Abemaciclib Standards
- Abemaciclib (CAS 1231929-97-7)
- Abemaciclib Impurity 82 (CAS CATO-C4X-293782)
- Abemaciclib Impurity 94 (CAS CATO-C4X-293794)
- Abemaciclib Impurity 139 (CAS CATO-C4X-2937139)
- Abemaciclib Impurity 122 (CAS CATO-C4X-2937122)
- Abemaciclib Impurity 56 (CAS CATO-C4X-293756)
- Abemaciclib-d5 (CAS 1809251-51-1)
- Abemaciclib-D8 (CAS 2088650-53-5)
Recommended Standards
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- Levosimendan Impurity 7 (CAS 134678-47-0)
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