Abemaciclib Impurity 141 CAS CATO-C4X-2937141
| CAS No. | CATO-C4X-2937141 |
| Molecular Formula | C22H24BrF3N4 |
| Molecular Weight | 481.35 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Abemaciclib Impurity 141 is closely related to a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/bromine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Abemaciclib Impurity 141 (CAS CATO-C4X-2937141) is a certified pharmaceutical impurity reference standard with the molecular formula C22H24BrF3N4 and a molecular weight of 481.35 g/mol.
The molecular framework of Abemaciclib Impurity 141 (C22H24BrF3N4) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/bromine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C22H24BrF3N4 |
| Molecular Weight | 481.35 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/Br-containing |
| Nitrogen Atoms | 4 |
Related Abemaciclib Standards
- Abemaciclib Impurity 142 (CAS CATO-C4X-2937142)
- Abemaciclib Impurity 136 (CAS CATO-C4X-2937136)
- Abemaciclib Impurity 178 (CAS 1942029-13-1)
- Abemaciclib Impurity 42 (CAS 1231930-57-6)
- Abemaciclib Impurity 6 (CAS CATO-C4X-29376)
- Abemaciclib Impurity 155 (CAS CATO-C4X-2937155)
- Abemaciclib Impurity 156 (CAS CATO-C4X-2937156)
- Abemaciclib Impurity 71 (CAS CATO-C4X-293771)
Recommended Standards
- 10-(4-(1-Benzyl-1H-1,2,3-triazol-4-yl)phenyl)-3,7-diethyl-5,5-difluoro-5H-dipyrrolo[1,2-c:2',1'-f][1,3,2]diazaborinin-4-ium-5-uide (CAS 1217340-99-2)
- 4-[5-(2,4-Dichlorophenyl)-1H-pyrazol-3-yl]-1-(2-nitrobenzenesulfonyl)piperidine (CAS 1031236-58-4)
- Methyl 4-((3-(2-(acetylthio)ethyl)-2-(methoxycarbonyl)phenoxy)methyl)-2-bromobenzoate (CAS 1029720-25-9)
- Ertugliflozin Impurity 52 (CAS CATO-C4X-301152)
- Indometacin Impurity 23 (CAS CATO-C4X-147023)
- Ziprasidone Impurity 65 (CAS CATO-C4X-124065)
- Olmesartan Impurity 14 (CAS 144978-05-2)
- 3-Fluoro-3-(fluoromethyl)azetidine (CAS 1466514-77-1)
- 5-Methyl-3-nitro-1H-pyrrolo[2,3-b]pyridine (CAS 1190321-24-4)
- Dicyclohexylamine (S)-2-((tert-butoxycarbonyl)amino)-3-methoxypropanoate (CAS 69912-63-6)
- 6-Methyl-1,2-benzisoxazol-3-ol (CAS 66571-26-4)
- 1-(2,4-Dinitrophenyl)-4-methylpiperazine (CAS 58910-37-5)
- [2-(trifluoromethyl)pyridin-4-yl]boronic acid (CAS 1093407-58-9)
- Exenatide (CAS 141758-74-9（free base）)
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