Abemaciclib Impurity 142 CAS CATO-C4X-2937142

Description

Compared with other compounds in its class, the molecular weight of 481.35 g/mol gives Abemaciclib Impurity 142 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.

Abemaciclib Impurity 142 (CAS CATO-C4X-2937142) is a certified pharmaceutical impurity reference standard with the molecular formula C22H24BrF3N4 and a molecular weight of 481.35 g/mol.

Based on its molecular formula C22H24BrF3N4, Abemaciclib Impurity 142 contains a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/bromine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 481.35 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.

Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.

The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.

Physical & Chemical Properties

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