Abemaciclib Impurity 136 CAS CATO-C4X-2937136
| CAS No. | CATO-C4X-2937136 |
| Molecular Formula | C25H30F2N8 |
| Molecular Weight | 480.56 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Abemaciclib Impurity 136 (C25H30F2N8) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Abemaciclib Impurity 136 (CAS CATO-C4X-2937136) is a certified pharmaceutical impurity reference standard with the molecular formula C25H30F2N8 and a molecular weight of 480.56 g/mol.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C25H30F2N8 |
| Molecular Weight | 480.56 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | ≥95% |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 8 |
Related Abemaciclib Standards
- Abemaciclib Impurity 141 (CAS CATO-C4X-2937141)
- Abemaciclib Impurity 142 (CAS CATO-C4X-2937142)
- Abemaciclib Impurity 42 (CAS 1231930-57-6)
- Abemaciclib Impurity 6 (CAS CATO-C4X-29376)
- Abemaciclib Impurity 178 (CAS 1942029-13-1)
- Abemaciclib Impurity 155 (CAS CATO-C4X-2937155)
- Abemaciclib Impurity 156 (CAS CATO-C4X-2937156)
- Abemaciclib Impurity 71 (CAS CATO-C4X-293771)
Recommended Standards
- Fluticasone Impurity 41 (CAS 192191-49-4)
- Belumosudil Impurity 54 (CAS CATO-C4X-298854)
- Dipyridamole EP Impurity F (CAS 60286-30-8)
- Linaprazan Impurity 8 (CAS CATO-C4X-34868)
- Trifarotene impurity 14 (CAS CATO-C4X-313214)
- Remimazolam Impurity 13 (CAS CATO-C4X-282313)
- Avatrombopag Impurity 61 (CAS CATO-C4X-223461)
- 5,6-bis(Methoxycarbonyl)-N,N,N-trimethyl-3-pyridinemethanaminium Bromide (CAS 150514-78-6)
- Ethyl (R)-3-amino-3-(3-fluoro-4-methoxyphenyl)propanoate (CAS 1917174-31-2)
- 2-(4-Methylphenyl)propane-d14 (CAS 93952-03-5)
- 5-(bromomethyl)-4-(methylsulfanyl)pyrrolo[2,1-f][1,2,4]triazine (CAS 1823897-62-6)
- Methyl 4-methyloctanoate (CAS 15870-07-2)
- Diisopropyl chloromalonate (CAS 195209-93-9)
- Semaglutide impurity 236 (CAS CATO-C4X-2226236)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com