Abemaciclib Impurity 176 CAS CATO-C4X-2937176
| CAS No. | CATO-C4X-2937176 |
| Molecular Formula | C12H18ClN3 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Based on its molecular formula C12H18ClN3HCl, Abemaciclib Impurity 176 contains a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 276.21 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
As a process- or degradation-related impurity, Abemaciclib Impurity 176 (CAS CATO-C4X-2937176, C12H18ClN3HCl) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C12H18ClN3 HCl |
| Molecular Weight | 276.21 g/mol |
| Purity | ≥95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Abemaciclib Standards
- Abemaciclib Impurity N5 (CAS 1038408-36-4)
- Abemaciclib Impurity 21 (CAS 1178566-47-6 (free base))
- Abemaciclib (CAS 1231929-97-7)
- Abemaciclib Impurity N2 (CAS 1231930-29-2)
- Abemaciclib Impurity N4 (CAS 1231930-33-8)
- Abemaciclib Impurity N7 (CAS 1231930-37-2)
- Abemaciclib Impurity N3 (CAS 1231930-42-9)
- Abemaciclib Impurity 70 (CAS 1231930-47-4)
Recommended Standards
- Oclacitinib Impurity 16 (CAS 2124221-18-5)
- Ilaprazole Impurity 122 (CAS CATO-C4X-1130122)
- Esomeprazole Impurity 116 (CAS 109371-19-9)
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- (R)-4-Amino-3-hydroxybutanoic acid (CAS 7013-07-2)
- Hexanedioic acid, 1,6-dimethyl ester, polymer with N1,N2-bis(2-aminoethyl)-1,2-ethanediamine and 1,5-dimethyl pentanedioate (CAS 72175-31-6)
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- N-phenethyl-2-(piperazin-1-yl)acetamide (CAS 685892-09-5)
- Semaglutide impurity 88 (CAS CATO-C4X-222688)
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