Abemaciclib Impurity 66 CAS CATO-C4X-293766
| CAS No. | CATO-C4X-293766 |
| Molecular Formula | C27H32F2N8O |
| Molecular Weight | 522.59 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Abemaciclib Impurity 66 (CAS CATO-C4X-293766, C27H32F2N8O) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Abemaciclib Impurity 66 (C27H32F2N8O) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C27H32F2N8O |
| Molecular Weight | 522.59 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 8 |
Related Abemaciclib Standards
- Abemaciclib Impurity 134 (CAS CATO-C4X-2937134)
- Abemaciclib Impurity 17 (CAS CATO-C4X-293717)
- Abemaciclib Impurity 18 (CAS CATO-C4X-293718)
- Abemaciclib Impurity 25 (CAS CATO-C4X-293725)
- Abemaciclib Impurity 68 (CAS 2138499-06-4)
- Abemaciclib Impurity 86 (CAS CATO-C4X-293786)
- Abemaciclib Impurity 87 (CAS CATO-C4X-293787)
- Abemaciclib Impurity 84 (CAS CATO-C4X-293784)
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