Abemaciclib Impurity 25 CAS CATO-C4X-293725
| CAS No. | CATO-C4X-293725 |
| Molecular Formula | C27H32F2N8O |
| Molecular Weight | 522.59 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Abemaciclib Impurity 25 (C27H32F2N8O) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Abemaciclib Impurity 25 (CAS CATO-C4X-293725) is a certified pharmaceutical impurity reference standard with the molecular formula C27H32F2N8O and a molecular weight of 522.59 g/mol.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Abemaciclib Impurity 25 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C27H32F2N8O |
| Molecular Weight | 522.59 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 8 |
Related Abemaciclib Standards
- Abemaciclib Impurity 134 (CAS CATO-C4X-2937134)
- Abemaciclib Impurity 17 (CAS CATO-C4X-293717)
- Abemaciclib Impurity 18 (CAS CATO-C4X-293718)
- Abemaciclib Impurity 66 (CAS CATO-C4X-293766)
- Abemaciclib Impurity 68 (CAS 2138499-06-4)
- Abemaciclib Impurity 86 (CAS CATO-C4X-293786)
- Abemaciclib Impurity 87 (CAS CATO-C4X-293787)
- Abemaciclib Impurity 84 (CAS CATO-C4X-293784)
Recommended Standards
- Daprodustat impurity 3 (CAS CATO-C4X-24073)
- Piperacillin-d5 (N-ethyl-d5) (CAS CATO-C4X-173258)
- β-Casomorphin (1-4) (bovine) (CAS 74171-19-0)
- TCS 2314 (CAS 317353-73-4)
- Betahistine Impurity 22 (CAS 49745-42-8)
- 2,2'-((2-((2-((carboxymethyl)amino)ethyl)amino)ethyl)azanediyl)diacetic acid (CAS 762191-10-6)
- Cholic Acid Impurity 83 (CAS CATO-C4X-116083)
- Tilfrinib (CAS 1600515-49-8)
- Testosterone Impurity 43 (CAS CATO-C4X-243243)
- 2-Benzyl-octahydro-cyclopenta[c]pyrrol-4-ylamine dihydrochloride (CAS 1956323-97-9)
- 5-amino-N-cyclopropyl-1H-1,2,3-triazole-4-carboxamide (CAS 1789455-92-0)
- Sitafloxacin Impurity 17 (CAS 127199-00-2)
- N-(tetrahydro-2H-pyran-4-yl)azetidin-3-amine dihydrochloride (CAS 2126159-68-8)
- Semaglutide Impurity 11 (CAS CATO-C4X-222611)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com