Abemaciclib Impurity 68 CAS 2138499-06-4
| CAS No. | 2138499-06-4 |
| Molecular Formula | C27H32F2N8O |
| Molecular Weight | 522.59 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Abemaciclib Impurity 68 (CAS 2138499-06-4) is a certified pharmaceutical impurity reference standard with the molecular formula C27H32F2N8O and a molecular weight of 522.59 g/mol.
Based on its molecular formula C27H32F2N8O, Abemaciclib Impurity 68 contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 522.59 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C27H32F2N8O |
| Molecular Weight | 522.59 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1997 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 8 |
Related Abemaciclib Standards
- Abemaciclib Impurity 134 (CAS CATO-C4X-2937134)
- Abemaciclib Impurity 17 (CAS CATO-C4X-293717)
- Abemaciclib Impurity 18 (CAS CATO-C4X-293718)
- Abemaciclib Impurity 25 (CAS CATO-C4X-293725)
- Abemaciclib Impurity 66 (CAS CATO-C4X-293766)
- Abemaciclib Impurity 86 (CAS CATO-C4X-293786)
- Abemaciclib Impurity 87 (CAS CATO-C4X-293787)
- Abemaciclib Impurity 84 (CAS CATO-C4X-293784)
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