Avacopan Impurity 10 CAS CATO-C4X-294510
| CAS No. | CATO-C4X-294510 |
| Molecular Formula | C33H36F3N3O2 |
| Molecular Weight | 563.65 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Avacopan Impurity 10 is closely related to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Avacopan Impurity 10 (CAS CATO-C4X-294510) is a certified pharmaceutical impurity reference standard with the molecular formula C33H36F3N3O2 and a molecular weight of 563.65 g/mol.
Avacopan Impurity 10 (C33H36F3N3O2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C33H36F3N3O2 |
| Molecular Weight | 563.65 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 16.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
Related Avacopan Standards
- Avacopan (CAS 1346623-17-3)
- Avacopan Impurity 12 (CAS CATO-C4X-294512)
- Avacopan impurity 7 (CAS 1257868-45-3)
- Avacopan Impurity 9 (CAS CATO-C4X-29459)
- Avacopan Impurity 1 (CAS CATO-C4X-29451)
- Avacopan Impurity 8 (CAS CATO-C4X-29458)
- Avacopan Impurity 4 (CAS 1346623-05-9)
- Avacopan Impurity 5 (CAS 1346623-09-3)
Recommended Standards
- Amoxicillin EP Impurity L (CAS 1789703-32-7)
- Ribociclib Impurity 34 (CAS CATO-C4X-310034)
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- Procollagen Type I (212-216) (CAS 149128-48-3)
- Tebipenem Impurity 13 (CAS CATO-C4X-134713)
- N-Acetyl Oxcarbazepine Impurity (CAS 28291-63-6)
- Rivaroxaban Impurity 181 (CAS CATO-C4X-1090181)
- Ido-in-12 (CAS 1888341-29-4)
- 1,3-Dibromo-5-(bromomethyl)-2-chlorobenzene (CAS 1350760-65-4)
- 5-Ethoxy-2-methylphenylboronic acid (CAS 1383576-05-3)
- (2S)-2-Amino-N-isopropyl-3-methyl-N-((1-methylpyrrolidin-3-yl)methyl)butanamide (CAS 1354032-81-7)
- 1-cyclopropylprop-2-en-1-ol (CAS 24897-34-5)
- 1-(3-(Trifluoromethyl)phenyl)-1H-pyrrole (CAS 53871-26-4)
- Semaglutide impurity 259 (CAS CATO-C4X-2226259)
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