Avacopan Impurity 4 CAS 1346623-05-9
| CAS No. | 1346623-05-9 |
| Molecular Formula | C27H33FN2O5 |
| Molecular Weight | 484.56 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
As a process- or degradation-related impurity, Avacopan Impurity 4 (CAS 1346623-05-9, C27H33FN2O5) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Avacopan Impurity 4 (C27H33FN2O5) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C27H33FN2O5 |
| Molecular Weight | 484.56 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Avacopan Standards
- Avacopan Impurity 5 (CAS 1346623-09-3)
- Avacopan Impurity 10 (CAS CATO-C4X-294510)
- Avacopan (CAS 1346623-17-3)
- Avacopan Impurity 12 (CAS CATO-C4X-294512)
- Avacopan impurity 7 (CAS 1257868-45-3)
- Avacopan Impurity 9 (CAS CATO-C4X-29459)
- Avacopan Impurity 2 (CAS 1346623-07-1)
- Avacopan Impurity 1 (CAS CATO-C4X-29451)
Recommended Standards
- Suvorexant Impurity 49 (CAS CATO-C4X-181249)
- Lobeglitazone-d4 (CAS CATO-CCAD304334)
- Fluticasone Propionate EP Impurity B (CAS 948566-12-9)
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- Adenosine Impurity 17 Trifluoroacetic acid (CAS CATO-C4X-241917)
- Pitavastatin Impurity 52 (CAS CATO-C4X-103752)
- Folic Acid EP Impurity G (CAS 2734707-85-6)
- 8-(5-Hexylfuran-2-yl)octanoic acid (CAS 4179-44-6)
- 1-(1-(4-Nitrophenyl)-1H-tetrazol-5-yl)piperidine (CAS 351870-70-7)
- 6-(tert-Butoxy)-3-cyclopropoxy-2-ethylpyridine (CAS 1243474-84-1)
- (2-Butoxy-5-chlorophenyl)methanol (CAS 23426-36-0)
- 4-(3-((4-Bromobenzyl)oxy)propyl)-1H-imidazole maleate (CAS 183155-85-3)
- Ethyl 2-(3,4-dimethylphenyl)-2-oxoacetate (CAS 80120-32-7)
- Semaglutide impurity 270 (CAS CATO-C4X-2226270)
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