Ivacaftor impurity 18 CAS CATO-C4X-296418
| CAS No. | CATO-C4X-296418 |
| Molecular Formula | C20H19N3O4 |
| Molecular Weight | 365.38 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Ivacaftor impurity 18 is closely related to a flavonoid core, an amide group, a hydroxyl group, an ether linkage in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
As a process- or degradation-related impurity, Ivacaftor impurity 18 (CAS CATO-C4X-296418, C20H19N3O4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Ivacaftor impurity 18 (C20H19N3O4) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Ivacaftor impurity 18 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C20H19N3O4 |
| Molecular Weight | 365.38 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 3 |
Related Ivacaftor Standards
Recommended Standards
- Finerenone Impurity 4 (CAS 2640280-86-8)
- Benzyl 2-(4-(methoxycarbonyl)phenyl)-4-oxo-3,4-dihydropyridine-1(2H)-carboxylate (CAS 2408761-16-8)
- Finerenone Impurity (CAS CATO-C4X-2880169)
- Adonifoline (CAS 115712-88-4)
- Finerenone Impurity 213 (CAS CATO-C4X-2880213)
- Gatifloxacin Impurity 16 (CAS 855997-06-7)
- Landiolol Impurity 28 (CAS CATO-C4X-262128)
- 1-(3-Amino-2-(4-chlorobenzoyl)-4-(trifluoromethyl)-7,8-dihydrothieno[2,3-b][1,6]naphthyridin-6(5H)-yl)ethan-1-one (CAS 727671-21-8)
- 2-Bromo-3-fluoro-4-picoline (CAS 884494-37-5)
- 3-methanesulfonylprop-2-enenitrile (CAS 1854-79-1)
- 3-Chloro-2,6-difluoropyridine (CAS 52208-56-7)
- 2-(Difluoromethyl)benzo[d]oxazole-4-acetic acid (CAS 1806490-80-1)
- Cadmium antimonide (CAS 12050-27-0)
- TRAF6 Control Peptide trifluoroacetate salt (CAS 852690-80-3)
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