Dabrafenib Impurity 4 CAS CATO-C4X-30334
| CAS No. | CATO-C4X-30334 |
| Molecular Formula | C18H12ClF2N3O4S |
| Molecular Weight | 439.82 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a process- or degradation-related impurity, Dabrafenib Impurity 4 (CAS CATO-C4X-30334, C18H12ClF2N3O4S) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, Dabrafenib Impurity 4 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 439.82 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
As a certified reference material (CRM), Dabrafenib Impurity 4 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C18H12ClF2N3O4S |
| Molecular Weight | 439.82 g/mol |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 1 |
Related Dabrafenib Standards
- Dabrafenib Impurity N6 (CAS 1195768-20-7)
- Dabrafenib Impurity 7 (CAS CATO-C4X-30337)
- Dabrafenib Impurity 5 (CAS CATO-C4X-30335)
- Dabrafenib Impurity 23 (CAS CATO-C4X-303323)
- Dabrafenib Impurity 10 (CAS CATO-C4X-303310)
- Dabrafenib Impurity 22 (CAS CATO-C4X-303322)
- Dabrafenib Impurity 32 (CAS CATO-C4X-303332)
- Dabrafenib Impurity 17 (CAS 1613724-51-8)
Recommended Standards
- N-(2-((1S,4R)-6-((4-chloro-5-(trifluoromethyl)pyrimidin-2-yl)amino)-1,2,3,4-tetrahydro-1,4-epiminonaphthalen-9-yl)-2-oxoethyl)acetamide (CAS 942492-29-7)
- (E)-({5-[(4-chlorophenyl)sulfanyl]-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl}methylidene)amino benzoate (CAS 321553-22-4)
- 6-(Benzylamino)-3-(2-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]amino}ethyl)-1,2,3,4-tetrahydropyrimidine-2,4-dione (CAS 306978-12-1)
- 1-[(4-Chlorophenyl)sulfanyl]-2-nitro-4-{[3-(trifluoromethyl)phenoxy]methyl}benzene (CAS 477869-53-7)
- Evocalcet Impurity 31 (CAS CATO-C4X-248531)
- Epinephrine /Adrenaline Impurity 139 (CAS CATO-C4X-1849139)
- Cefotiam Impurity 41 (CAS 61607-68-9)
- 3-((4-(Tert-butyl)thiazol-2-yl)amino)benzo[d]isothiazole 1,1-dioxide (CAS 693815-11-1)
- Norepinephrine Impurity 31 (CAS CATO-C4X-1514131)
- Methyl 3-[2-(dimethylsulfamoyl)phenyl]-5-fluorobenzoate (CAS 1820734-79-9)
- Butralin (CAS 33629-47-9)
- 4,4'-(Ethane-1,2-diylbis(azaneylylidene))bis(1,1,1,7,7,7-hexafluoro-2,6-bis(trifluoromethyl)heptane-2,6-diol) (CAS 824414-01-9)
- 4-(6-Chloropyrazin-2-yl)benzoic acid (CAS 1086379-53-4)
- Peptide YY (13-36) (canine, mouse, porcine, rat) (CAS 86895-09-2)
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