Dabrafenib Impurity 7 CAS CATO-C4X-30337
| CAS No. | CATO-C4X-30337 |
| Molecular Formula | C18H12F3N3O4S |
| Molecular Weight | 423.37 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Dabrafenib Impurity 7 is closely related to a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Dabrafenib Impurity 7 (CAS CATO-C4X-30337) is a certified pharmaceutical impurity reference standard with the molecular formula C18H12F3N3O4S and a molecular weight of 423.37 g/mol.
The molecular framework of Dabrafenib Impurity 7 (C18H12F3N3O4S) is characterized by a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C18H12F3N3O4S |
| Molecular Weight | 423.37 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 1 |
Related Dabrafenib Standards
- Dabrafenib Impurity 5 (CAS CATO-C4X-30335)
- Dabrafenib Impurity 4 (CAS CATO-C4X-30334)
- Dabrafenib Impurity N6 (CAS 1195768-20-7)
- Dabrafenib Impurity 23 (CAS CATO-C4X-303323)
- Dabrafenib Impurity 10 (CAS CATO-C4X-303310)
- Dabrafenib Impurity 22 (CAS CATO-C4X-303322)
- Dabrafenib Impurity 32 (CAS CATO-C4X-303332)
- Dabrafenib Impurity 27 (CAS CATO-C4X-303327)
Recommended Standards
- Cabotegravir Impurity 22 (CAS 2883234-38-4)
- 5-Oxo-8-(phenylsulfonyl)-1,2,3,5-tetrahydroindolizin-6-yl trifluoromethanesulfonate (CAS 185198-44-1)
- Cabotegravir Impurity 21 (CAS 2883234-40-8)
- 2,4-Bis({[(4-chlorophenyl)methyl]sulfanyl})-5-methoxypyrimidine (CAS 338423-20-4)
- Methoxamine Impurity 5 (CAS 90253-98-8)
- Etoricoxib Impurity 75 (CAS 40061-49-2)
- Dexamethasone Impurity 116 (CAS 107419-73-8)
- 5,6,7,8-tetrahydro-[1,2,4]triazolo[1,5-b]pyridazine (CAS 51519-58-5)
- prop-2-ynylsulfonylbenzene (CAS 2525-40-8)
- 2-Chloro-5-methoxymethylphenylboronic acid (CAS 1451392-23-6)
- Methane Disulfonic Acid (CAS 503-40-2)
- Inotilone (CAS 906366-79-8)
- 9-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1H-purine-6(9H)-thione (CAS 109304-05-4)
- Insulin Degludec Impurity 19 (CAS CATO-C4X-215719)
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