Lemborexant Impurity 92 CAS CATO-C4X-304292
| CAS No. | CATO-C4X-304292 |
| Molecular Formula | C11H9FO2 |
| Molecular Weight | 192.19 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Lemborexant Impurity 92.
As a process- or degradation-related impurity, Lemborexant Impurity 92 (CAS CATO-C4X-304292, C11H9FO2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Lemborexant Impurity 92 (C11H9FO2) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C11H9FO2 |
| Molecular Weight | 192.19 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | ≥95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
Related Lemborexant Standards
- Lemborexant impurity 4 (CAS 528587-70-4)
- Lemborexant Impurity 53 (CAS CATO-C4X-304253)
- Lemborexant Impurity 61 (CAS 528587-69-1)
- Lemborexant Impurity 62 (CAS CATO-C4X-304262)
- Lemborexant Impurity 75 (CAS 2412536-16-2)
- Lemborexant Impurity 93 (CAS CATO-C4X-304293)
- Lemborexant impurity 3 (CAS 571189-49-6)
- Lemborexant Impurity 38 (CAS 1450904-98-9)
Recommended Standards
- 4-(Trifluoromethyl)benzyl mercaptan (CAS 108499-24-7)
- 1-(1,1-Difluoroethyl)naphthalene (CAS 1204295-97-5)
- 2-(1,1-Difluoroethyl)naphthalene (CAS 1204296-00-3)
- 2-Methyl-3-trifluoromethylbenzenethiol (CAS 1208075-42-6)
- Regorafenib Impurity 71 (CAS CATO-C4X-104771)
- Folic Acid EP Impurity D (CAS 119-24-4)
- Tepotinib impurity 21 (CAS CATO-C4X-337421)
- 11-cis-Retinoic Acid Methyl Ester (CAS 25428-67-5)
- n-(2-Benzoylphenyl)-3-chloropropanamide (CAS 950029-14-8)
- (4-Benzoylpiperazin-1-yl)(3-chlorophenyl)methanone (CAS 708981-95-7)
- 2-Amino-3-(3-phenoxyphenyl)propanoic acid hydrochloride (CAS 119349-34-7)
- (6R,7S)-Cefuroxime Isomer (CAS CATO-C4X-124519)
- 1,4-Dibenzylbenzene (CAS 793-23-7)
- Gastric Inhibitory Polypeptide (human) (CAS 100040-31-1)
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