Acalabrutinib Impurity 1 CAS CATO-C4X-30551
| CAS No. | CATO-C4X-30551 |
| Molecular Formula | C26H25N7O3 |
| Molecular Weight | 483.52 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Acalabrutinib Impurity 1 (C26H25N7O3) contains a steroid core, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Acalabrutinib Impurity 1 (CAS CATO-C4X-30551) is a certified pharmaceutical impurity reference standard with the molecular formula C26H25N7O3 and a molecular weight of 483.52 g/mol.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Acalabrutinib Impurity 1 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C26H25N7O3 |
| Molecular Weight | 483.52 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 18.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 7 |
Related Acalabrutinib Standards
- Acalabrutinib-D4 (CAS 1420477-60-6(Unlabelled))
- Acalabrutinib Impurity 22 (CAS CATO-C4X-305522)
- Acalabrutinib Impurity N1 (CAS 1952316-43-6)
- Acalabrutinib (CAS 1420477-60-6)
- Acalabrutinib Impurity 18 (CAS CATO-C4X-305518)
- Acalabrutinib Impurity 19 (CAS CATO-C4X-305519)
- Acalabrutinib Impurity 23 (CAS CATO-C4X-305523)
- Acalabrutinib Impurity 21 (CAS 2412166-56-2)
Recommended Standards
- Cabozantinib Impurity 45 (CAS CATO-C4X-201845)
- Vazegepant Impurity 16 (CAS CATO-C4X-320016)
- Cabozantinib Impurity 13 (CAS 849221-94-9)
- Etrasimod Impurity 68 (CAS CATO-C4X-321468)
- Tirofiban Impurity 21 (CAS CATO-C4X-125421)
- Daptomycin Impurity 56 (CAS CATO-C4X-137856)
- Isoflurane EP Impurity D (CAS 32778-07-7)
- Di-μ-chlorotetrakis[(1,2-η)-cyclooctene]dirhodium (CAS 63902-12-5)
- (2S,3S)-2,5-Dioxopyrrolidin-1-yl 2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-methylpentanoate (CAS 121697-35-6)
- 4-Amino-N-(4-(phenylamino)phenyl)benzenesulfonamide (CAS 327070-73-5)
- 1,4-Diiodo-2-nitrobenzene (CAS 89488-57-3)
- Linezolid Impurity 96 (CAS 152139-76-9)
- 6-Methoxypyridine-2-carbothioamide (CAS 134789-88-1)
- a2,3-Sialylglycopeptide (CAS 189035-43-6)
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