Acalabrutinib Impurity 7 CAS CATO-C4X-30557
| CAS No. | CATO-C4X-30557 |
| Molecular Formula | C10H12BrN5 |
| Molecular Weight | 282.14 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Acalabrutinib Impurity 7 (CAS CATO-C4X-30557) is a certified pharmaceutical impurity reference standard with the molecular formula C10H12BrN5 and a molecular weight of 282.14 g/mol.
The molecular framework of Acalabrutinib Impurity 7 (C10H12BrN5) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, bromine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H12BrN5 |
| Molecular Weight | 282.14 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 5 |
Related Acalabrutinib Standards
- Acalabrutinib Impurity 6 (CAS CATO-C4X-30556)
- Acalabrutinib Impurity 25 (CAS CATO-C4X-305525)
- Acalabrutinib Impurity 8 (CAS CATO-C4X-30558)
- Acalabrutinib Impurity 29 (CAS CATO-C4X-305529)
- Acalabrutinib Impurity 11 (CAS CATO-C4X-305511)
- Acalabrutinib Impurity 30 (CAS CATO-C4X-305530)
- Acalabrutinib Impurity 24 (CAS 2097352-14-0)
- Acalabrutinib Impurity 31 (CAS CATO-C4X-305531)
Recommended Standards
- 864932-42-3 4-(4-Bromophenyl)-2-isopropyl-2,4-dihydro-3H-1,2,4-triazol-3-one MFCD18074538 (CAS 864932-42-3)
- 2,4-Dichloro-6-(methylsulfonyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine (CAS 1048389-75-8)
- Trifluoromethanesulfonic anhydride (CAS 358-23-6)
- 2-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)pyrimidine (CAS 1220526-74-8)
- Crisaborole lmpurity 93 (CAS CATO-C4X-202193)
- Methoxamine Impurity 16 (CAS 121347-31-7)
- Fosfomycin Impurity 22 (CAS CATO-C4X-131622)
- 1-(2,3-Dimethylphenyl)-piperazine (CAS 1013-22-5)
- Cimetidine impurity 26 (CAS 208447-53-4)
- 5-Amino-6-hydroxypyrimidin-4(3H)-one hydrochloride (CAS 857202-31-4)
- Trimidox - API Standards (CAS 95933-74-7)
- 3-(2,6-Dioxopiperidin-3-yl)benzo[d]isoxazole-5-carboxylic acid (CAS 2623103-36-4)
- 6-Ethyl-1H-pyrrolo[2,3-b]pyridine (CAS 533939-04-7)
- D-Ile27-Tirzepatide (CAS CATO-CPTD788907)
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