Ribociclib Impurity 16 CAS CATO-C4X-310016
| CAS No. | CATO-C4X-310016 |
| Molecular Formula | C28H41N7O4 |
| Molecular Weight | 539.67 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Ribociclib Impurity 16 is closely related to a steroid core, an amide group, a hydroxyl group, an ether linkage in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
As a process- or degradation-related impurity, Ribociclib Impurity 16 (CAS CATO-C4X-310016, C28H41N7O4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Ribociclib Impurity 16 (C28H41N7O4) contains a steroid core, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Ribociclib Impurity 16 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C28H41N7O4 |
| Molecular Weight | 539.67 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 7 |
Related Ribociclib Standards
- Ribociclib Impurity 34 (CAS CATO-C4X-310034)
- Ribociclib Impurity 20 (CAS CATO-C4X-310020)
- Ribociclib Impurity 44 (CAS CATO-C4X-310044)
- Ribociclib Impurity 41 (CAS CATO-C4X-310041)
- Ribociclib impurity 1 (CAS CATO-C4X-31001)
- Ribociclib Impurity 21 (CAS CATO-C4X-310021)
- Ribociclib Impurity 19 (CAS CATO-C4X-310019)
- Ribociclib Impurity 23 (CAS CATO-C4X-310023)
Recommended Standards
- 5-((3-(4-(Allyloxy)phenyl)-1-phenyl-1H-pyrazol-4-yl)methylene)-3-(4-methoxybenzyl)-2-thioxothiazolidin-4-one (CAS 623934-78-1)
- Atrasentan Impurity 130 (CAS 1063836-11-2)
- 1-(Bromomethyl)-3,5-bis(dodecyloxy)benzene (CAS 429696-61-7)
- Atrasentan Impurity 161 (CAS 1063835-86-8)
- Ilaprazole impurity 184 (CAS CATO-C4X-1130184)
- Sibutramine Impurity 6 (CAS 2758418-79-8)
- Dutaverine Impurity 34 HCl (CAS CATO-C4X-243534)
- 2-(1,1,1,3,3,3-Hexafluoropropan-2-yloxy)-5-(trifluoromethyl)pyridine (CAS 1779128-02-7)
- 2,5-Difluoro-3-nitrobenzonitrile (CAS 1690818-46-2)
- N,5-Dimethyl-2-phenyl-2H-1,2,3-triazole-4-carboxamide (CAS 923217-20-3)
- N-(2-(1H-indol-3-yl)ethyl)-2-(4-(tert-butyl)phenoxy)nicotinamide (CAS 497060-34-1)
- 5-Chloro-4-fluoro-2-(trifluoromethyl)benzaldehyde (CAS 134099-23-3)
- 2-(3-(Triethylammonio)propyl)isoquinolin-2-ium bromide (CAS 64047-69-4)
- Peptide 433 (CAS CATO-CPTD788433)
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