HISTIDINE Impurity 12 CAS CATO-C4X-323912
| CAS No. | CATO-C4X-323912 |
| Molecular Formula | C6H9N3O3 |
| Molecular Weight | 171.15 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 171.15 g/mol gives HISTIDINE Impurity 12 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
HISTIDINE Impurity 12 (CAS CATO-C4X-323912) is a certified pharmaceutical impurity reference standard with the molecular formula C6H9N3O3 and a molecular weight of 171.15 g/mol.
HISTIDINE Impurity 12 (C6H9N3O3) contains an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), HISTIDINE Impurity 12 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C6H9N3O3 |
| Molecular Weight | 171.15 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 3 |
Related HISTIDINE Standards
- HISTIDINE impurity 3 (CAS CATO-C4X-32393)
- HISTIDINE Impurity 6 (CAS 1932060-69-9)
- D-Histidine Methyl Ester (CAS 17720-12-6)
- HISTIDINE Impurity N1 (CAS CATO-C1416939)
- L-Histidine-13C6 (CAS 55443-59-9)
- HISTIDINE Impurity 8 (CAS CATO-C4X-32398)
- HISTIDINE Impurity 9 (CAS CATO-C4X-32399)
- HISTIDINE Impurity 13 (CAS CATO-C4X-323913)
Recommended Standards
- 2-Oxohistidine (CAS 181996-08-7)
- Pyridoxine Impurity 6 (CAS 23429-05-2)
- N-Nitroso Piperacillin impurity 103 (CAS CATO-C4X-1732103)
- Metronidazole (CAS 443-48-1)
- Dexrazoxane Impurity 33 (CAS 15250-41-6)
- Ivabradine impurity 80 (CAS CATO-C4X-111980)
- Oseltamivir Impurity 89 (CAS 1234858-94-6)
- N-(3,5-Dimethoxy-2-nitrophenyl)acetamide (CAS 1075748-42-3)
- 2-(3-Bromo-4-methylphenoxy)ethan-1-ol (CAS 1851181-29-7)
- 3-Nitropyridin-4(1H)-one (CAS 15590-90-6)
- 0656AF 850074-81-6 C14H12O3S Ethyl 5-(4-formylphenyl)-2-thiophenecarboxylate (CAS 850074-81-6)
- 2-(Ethylthio)-1-(4-fluorophenyl)-5-(p-tolyl)-1H-imidazole (CAS 1207057-66-6)
- 4-Carboxybenzenesulfonyl azide (CAS 17202-49-2)
- Semaglutide Impurity 82 (CAS CATO-C4X-222682)
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