HISTIDINE impurity 3 CAS CATO-C4X-32393
| CAS No. | CATO-C4X-32393 |
| Molecular Formula | C6H9N3O3 |
| Molecular Weight | 171.15 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Based on its molecular formula C6H9N3O3, HISTIDINE impurity 3 contains an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 171.15 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
As a process- or degradation-related impurity, HISTIDINE impurity 3 (CAS CATO-C4X-32393, C6H9N3O3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C6H9N3O3 |
| Molecular Weight | 171.15 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 3 |
Related HISTIDINE Standards
- HISTIDINE Impurity 12 (CAS CATO-C4X-323912)
- HISTIDINE Impurity 6 (CAS 1932060-69-9)
- D-Histidine Methyl Ester (CAS 17720-12-6)
- HISTIDINE Impurity N1 (CAS CATO-C1416939)
- L-Histidine-13C6 (CAS 55443-59-9)
- HISTIDINE Impurity 8 (CAS CATO-C4X-32398)
- HISTIDINE Impurity 9 (CAS CATO-C4X-32399)
- HISTIDINE Impurity 13 (CAS CATO-C4X-323913)
Recommended Standards
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- Metronidazole (CAS 443-48-1)
- Pyridoxine Impurity 6 (CAS 23429-05-2)
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- Sulpiride impurity 14 (CAS CATO-C4X-187614)
- Tucatinib Impurity 10 (CAS CATO-C4X-260510)
- Vonoprazan Impurity 49 (CAS CATO-C4X-1020249)
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- 6-Bromo-1-chloro-4-fluoroisoquinoline (CAS 1976053-18-5)
- Methyl 1-benzyl-2-imino-10-methyl-5-oxo-2,5-dihydro-1H-dipyrido[1,2-a:2',3'-d]pyrimidine-3-carboxylate (CAS 371926-99-7)
- Ethyl 4-methyl-3,4-dihydro-2H-pyrrole-4-carboxylate (CAS 148028-68-6)
- 1-{4-[3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}methanamine,HCl (CAS 1820736-42-2)
- 915019-08-8 55R7RG342O Tertomotide [INN] Human telomerase reverse transcriptase (EC 2.7.7.49)-(611-626)-peptide (telomerase catalytic subunit fragment) Tertomotide UNII-55R7RG342O GV 1001 GV-1001 (CAS 915019-08-8)
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