Halobetasol Propionate Impurity 14 CAS CATO-C4X-331414
| CAS No. | CATO-C4X-331414 |
| Molecular Formula | C22H28ClFO5 |
| Molecular Weight | 426.91 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Halobetasol Propionate Impurity 14.
Halobetasol Propionate Impurity 14 (CAS CATO-C4X-331414) is a certified pharmaceutical impurity reference standard with the molecular formula C22H28ClFO5 and a molecular weight of 426.91 g/mol.
The molecular framework of Halobetasol Propionate Impurity 14 (C22H28ClFO5) is characterized by a flavonoid core, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Halobetasol Propionate Impurity 14 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C22H28ClFO5 |
| Molecular Weight | 426.91 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/Cl-containing |
Related Halobetasol Standards
- Halobetasol (CAS 98651-66-2)
- Halobetasol Impurity 8 (CAS CATO-C4X-33148)
- Halobetasol Impurity 7 (CAS 32232-54-5)
- Halobetasol Impurity 13 (CAS CATO-C4X-331413)
- Halobetasol Impurity 9 (CAS CATO-C4X-33149)
- Halobetasol Impurity 10 (CAS CATO-C4X-331410)
- Halobetasol Impurity 3 (CAS 181527-42-4)
- Halobetasol Impurity 4 (CAS CATO-C4X-33144)
Recommended Standards
- Fluticasone Furoate Impurity 2 (CAS 1355648-15-5)
- 2,2'-(5-Bromo-2-fluoro-1,3-phenylene)bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolane) (CAS 942069-49-0)
- Fluticasone Impurity 68 (CAS 1744-64-5)
- 3-((4-Chlorophenyl)thio)-10-methyl-7H-benzo[de]benzo[4,5]imidazo[2,1-a]isoquinolin-7-one (CAS 97416-81-4)
- Chlorpromazine Hydrochloride EP Impurity F (CAS 72372-62-4)
- Daptomycin impurity 53 (CAS CATO-C4X-137853)
- Dapoxetine Impurity 7 (CAS CATO-C4X-14397)
- 4-(3,5-Dimethylphenyl)-2,6-di-p-tolylpyridine (CAS 1868146-05-7)
- 3,3-difluoro-5-(iodomethyl)oxolan-2-one (CAS 1256080-97-3)
- 6-(Hydroxymethyl)indolin-2-one (CAS 1093086-32-8)
- (S)-2-((1H-benzo[d]imidazol-4-yl)oxy)propanoic acid (CAS 2068138-05-4)
- Methyl 4-(hydroxymethyl)piperidine-4-carboxylate (CAS 1006044-28-5)
- (2-(Pyrimidin-2-ylthio)ethyl)boronic acid (CAS 89641-17-8)
- Liraglutide-d8 Tetratrifluoroacetate (CAS 204656-20-2 (non-labelled, free base))
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