Fluticasone Furoate Impurity 2 CAS 1355648-15-5
| CAS No. | 1355648-15-5 |
| Molecular Formula | C22H28ClFO5 |
| Molecular Weight | 426.91 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Fluticasone Furoate Impurity 2 (CAS 1355648-15-5, C22H28ClFO5) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Fluticasone Furoate Impurity 2 (C22H28ClFO5) contains a flavonoid core, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 8.0, corresponding to approximately 8 ring(s) or double-bond equivalent(s). With a molecular weight of 426.91 g/mol, it falls into the moderately-high-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C22H28ClFO5 |
| Molecular Weight | 426.91 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | F/Cl-containing |
Related Fluticasone Standards
- Fluticasone Impurity 101 (CAS CATO-C4X-1650101)
- Fluticasone Impurity 49 (CAS CATO-C4X-165049)
- Fluticasone Impurity 68 (CAS 1744-64-5)
- Fluticasone Impurity 106 (CAS CATO-C4X-1650106)
- Fluticasone Impurity 111 (CAS 785806-92-0)
- Fluticasone Impurity 112 (CAS CATO-C4X-1650112)
- Fluticasone Impurity 54 (CAS 4571-51-1)
- Fluticasone Impurity 96 (CAS CATO-C4X-165096)
Recommended Standards
- Halobetasol Propionate Impurity 14 (CAS CATO-C4X-331414)
- 2,2'-(5-Bromo-2-fluoro-1,3-phenylene)bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolane) (CAS 942069-49-0)
- 3-((4-Chlorophenyl)thio)-10-methyl-7H-benzo[de]benzo[4,5]imidazo[2,1-a]isoquinolin-7-one (CAS 97416-81-4)
- Halometasone impurity 14 (CAS CATO-C4X-144614)
- CAS 230615-12-0 (CAS 230615-12-0)
- Fingolimod impurity 24 (CAS CATO-C4X-164624)
- Metaraminol Impurity 97 (CAS CATO-C4X-225297)
- (3S,4R)-4-Fluoropiperidin-3-ol (CAS 1932816-28-8)
- Carbamazepine Impurity 16 (CAS CATO-C4X-118116)
- 1,1-Dixoide-4-thiomorpholine Propanoic Acid Hydrochloride (CAS 857473-42-8)
- Biotin Impurity 04 (CAS 26339-40-2)
- 7-Methoxyimidazo[1,2-a]pyridine-8-carboxylic acid (CAS 834868-56-3)
- Methyl 4-(((benzyloxy)carbonyl)amino)bicyclo[2.2.1]heptane-1-carboxylate (CAS 1252672-35-7)
- Semaglutide impurity 195 (CAS CATO-C4X-2226195)
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