Aprocitentan Impurity 8 CAS CATO-C4X-33558
| CAS No. | CATO-C4X-33558 |
| Molecular Formula | C16H12Br2N6O3 |
| Molecular Weight | 496.11 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Aprocitentan Impurity 8 (CAS CATO-C4X-33558, C16H12Br2N6O3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, bromine substitution, Aprocitentan Impurity 8 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 496.11 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Aprocitentan Impurity 8 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C16H12Br2N6O3 |
| Molecular Weight | 496.11 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | ≥95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 6 |
Related Aprocitentan Standards
- Aprocitentan impurity 2 (CAS CATO-C4X-33552)
- Aprocitentan-d4 (CAS CATO-C4X-335510)
- Aprocitentan Impurity 4 (CAS CATO-C4X-33554)
- Aprocitentan Impurity 5 (CAS CATO-C4X-33555)
- Aprocitentan Impurity 6 (CAS CATO-C4X-33556)
- Aprocitentan Impurity 7 (CAS CATO-C4X-33557)
- Aprocitentan Impurity 9 (CAS CATO-C4X-33559)
- Aprocitentan impurity 1 (CAS CATO-C4X-33551)
Recommended Standards
- (1E)-1-[2-(4-Bromo-2-fluorophenoxy)phenyl]-N-(4-iodophenyl)methanimine (CAS 477886-96-7)
- (3-(5-(Dimethylamino)-6-iodonaphthalene-1-sulfonamido)phenyl)boronic acid (CAS 147353-58-0)
- 4-Iodo-2-heptafluoropropoxy-1,1,1,2-tetrafluorooctane (CAS 261760-05-8)
- 1-(3-(Perfluorohexyl)-5-(trifluoromethyl)-1H-pyrazol-1-yl)ethan-1-one (CAS 231301-29-4)
- Daunorubicin HCl EP Impurity F (CAS 771423-67-7)
- Guaiazulene Impurity 8 (CAS CATO-C4X-22378)
- Letermovir impurity 138 (CAS CATO-C4X-2915138)
- 2-(Furan-2-yl)-6-iodoimidazo[1,2-a]pyridine (CAS 61982-64-7)
- N-cyclopentylpiperidine-4-carboxamide (CAS 946744-00-9)
- (4-(3,5-Difluorophenoxy)phenyl)boronic acid (CAS 1029438-51-4)
- 3,4-Diaminobenzenesulfonic acid (CAS 7474-78-4)
- 3-Amino-6-(cyanomethyl)pyrazine-2-carbonitrile (CAS 61267-56-9)
- 1,3-Bis(ethoxycarbonyl)-2-methylisothiourea (CAS 34840-26-1)
- Peptide Impurity 70 TFA Salt (CAS CATO-CPTD788570)
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