Aprocitentan Impurity 9 CAS CATO-C4X-33559
| CAS No. | CATO-C4X-33559 |
| Molecular Formula | C12H11BrN2O3 |
| Molecular Weight | 311.13 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 311.13 g/mol gives Aprocitentan Impurity 9 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
CATO supplies Aprocitentan Impurity 9 (CAS CATO-C4X-33559), a pharmacopoeial impurity reference standard (molecular formula C12H11BrN2O3, MW 311.13 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Aprocitentan Impurity 9 (C12H11BrN2O3) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, bromine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C12H11BrN2O3 |
| Molecular Weight | 311.13 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | ≥95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 2 |
Related Aprocitentan Standards
- Aprocitentan Impurity 6 (CAS CATO-C4X-33556)
- Aprocitentan Impurity 7 (CAS CATO-C4X-33557)
- Aprocitentan impurity 1 (CAS CATO-C4X-33551)
- Aprocitentan Impurity 8 (CAS CATO-C4X-33558)
- Aprocitentan impurity 2 (CAS CATO-C4X-33552)
- Aprocitentan-d4 (CAS CATO-C4X-335510)
- Aprocitentan Impurity 4 (CAS CATO-C4X-33554)
- Aprocitentan Impurity 5 (CAS CATO-C4X-33555)
Recommended Standards
- Rebamipide Impurity 62 (CAS 889573-80-2)
- (2-((Benzyloxy)carbonyl)-1,2,3,4-tetrahydroisoquinolin-6-yl)boronic acid (CAS 1020173-39-0)
- methyl 5-[(4-bromophenoxy)methyl]-2-furoate (CAS 402771-33-9)
- (4-(1-(((Benzyloxy)carbonyl)amino)cyclopropyl)phenyl)boronic acid (CAS 1217501-09-1)
- Bromocriptine EP Impurity D (CAS 478-83-1)
- Fulvestrant Impurity 24 (CAS CATO-C4X-191724)
- Sunitinib Impurity 58 (CAS 17106-12-6)
- 4-((4-Hydroxy-6-oxo-1,6-dihydropyrimidin-2-yl)amino)benzonitrile (CAS 374067-80-8)
- Olaparib Impurity 36 (CAS CATO-C4X-113536)
- n-(1-Ethyl-1h-pyrazol-4-yl)hydrazinecarboximidamide (CAS 1344848-12-9)
- (R)-Benzyl (1-aminopropan-2-yl)carbamate hydrochloride (CAS 850033-74-8)
- 4-Bromo-2-(difluoromethyl)-3,5-dimethoxypyridine (CAS 1803707-32-5)
- 3-Methyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid (CAS 2013-90-3)
- Semaglutide Impurity 189 (CAS CATO-C4X-2226189)
Why CATO?
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