Clobetasone butyrate EP Impurity G CAS CATO-C4X-35394
| CAS No. | CATO-C4X-35394 |
| Molecular Formula | C29H37FO7 |
| Molecular Weight | 516.60 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Clobetasone butyrate EP Impurity G (CAS CATO-C4X-35394) is a certified pharmaceutical impurity reference standard with the molecular formula C29H37FO7 and a molecular weight of 516.60 g/mol.
The molecular framework of Clobetasone butyrate EP Impurity G (C29H37FO7) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, a polycyclic aromatic system. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Clobetasone butyrate EP Impurity G meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C29H37FO7 |
| Molecular Weight | 516.60 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | ≥95% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
Related Clobetasone Standards
- Clobetasone Butyrate Impurity 7 (CAS CATO-C4X-35397)
- Clobetasone butyrate EP Impurity E (CAS 639817-48-4)
- Clobetasone butyrate EP Impurity C (CAS 639817-49-5)
- Clobetasone Butyrate EP Impurity I (CAS 639817-47-3)
- Clobetasone Butyrate EP Impurity F (CAS 25120-98-3)
- Clobetasone 17-Butyrate (CAS 25122-57-0)
- Clobetasone Butyrate EP Impurity D (CAS 639817-51-9)
- Clobetasone Butyrate EP Impurity H (CAS 25122-56-9)
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Why CATO?
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