Clobetasone Butyrate EP Impurity F CAS 25120-98-3

Purity ≥95%In StockPharmacopoeial Impurity Standards
CAS No.25120-98-3
Molecular FormulaC26H32ClFO5
Molecular Weight478.98 g/mol
CategoryPharmacopoeial Impurity Standards / EP Impurities
AvailabilityIn Stock

Chemical Structure

Clobetasone Butyrate EP Impurity F CAS 25120-98-3 chemical structure

Description

Compared with other compounds in its class, the molecular weight of 478.98 g/mol gives Clobetasone Butyrate EP Impurity F distinctive chromatographic separation conditions and mass-spectrometry parameter settings.

CATO supplies Clobetasone Butyrate EP Impurity F (CAS 25120-98-3), a pharmacopoeial impurity reference standard (molecular formula C26H32ClFO5, MW 478.98 g/mol) used for the identification and quantification of trace impurities in APIs.

Structurally, Clobetasone Butyrate EP Impurity F (C26H32ClFO5) contains a steroid core, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 10.0, corresponding to approximately 10 ring(s) or double-bond equivalent(s). With a molecular weight of 478.98 g/mol, it falls into the moderately-high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).

This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.

CATO manufactures Clobetasone Butyrate EP Impurity F under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.

Physical & Chemical Properties

Molecular FormulaC26H32ClFO5
Molecular Weight478.98 g/mol
AppearancePale yellow to yellow crystalline powder. (slight halide-like odor, low volatility)
Purity≥95%
StorageStore at room temperature, protect from light, keep sealed and dry
Solubility (reference)Soluble in methanol, acetonitrile, DMSO, water (slightly soluble)
StabilityMay oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions
Degree of Unsaturation (DBE)10.0
UV AbsorptionUV-absorbing
Structural FeaturesAromatic ring present
CAS Registry Year (est.)1964
Halogen ContentF/Cl-containing

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