Clobetasone butyrate EP Impurity E CAS 639817-48-4

Purity ≥95%In StockPharmacopoeial Impurity Standards
CAS No.639817-48-4
Molecular FormulaC26H34ClFO5
Molecular Weight481.00 g/mol
CategoryPharmacopoeial Impurity Standards / EP Impurities
AvailabilityIn Stock

Chemical Structure

Clobetasone butyrate EP Impurity E CAS 639817-48-4 chemical structure

Description

Compared with other compounds in its class, the molecular weight of 481.00 g/mol gives Clobetasone butyrate EP Impurity E distinctive chromatographic separation conditions and mass-spectrometry parameter settings.

CATO supplies Clobetasone butyrate EP Impurity E (CAS 639817-48-4), a pharmacopoeial impurity reference standard (molecular formula C26H34ClFO5, MW 481.00 g/mol) used for the identification and quantification of trace impurities in APIs.

Clobetasone butyrate EP Impurity E (C26H34ClFO5) contains a steroid core, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. Halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.

Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.

The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.

Physical & Chemical Properties

Molecular FormulaC26H34ClFO5
Molecular Weight481.00 g/mol
AppearancePale yellow to yellow crystalline powder. (slight halide-like odor, low volatility)
Purity≥95%
StorageStore at room temperature, protect from light, keep sealed and dry
Solubility (reference)Soluble in methanol, acetonitrile, DMSO, water (slightly soluble)
StabilityMay oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions
Degree of Unsaturation (DBE)9.0
UV AbsorptionUV-absorbing
Structural FeaturesAromatic ring present
CAS Registry Year (est.)1985
Halogen ContentF/Cl-containing

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