Trazodone Impurity N13 CAS 101364-27-6
| CAS No. | 101364-27-6 |
| Molecular Formula | C13H17Cl3N2 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 344.10 g/mol gives Trazodone Impurity N13 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
Trazodone Impurity N13 (CAS 101364-27-6) is a certified pharmaceutical impurity reference standard with the molecular formula C13H17Cl3N2HCl and a molecular weight of 344.10 g/mol.
Owing to a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution, Trazodone Impurity N13 is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 344.10 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C13H17Cl3N2 HCl |
| Molecular Weight | 344.10 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1985 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Trazodone Standards
- Trazodone D6 (CAS 1181578-48-2)
- Trazodone-d6 Hydrochloride (CAS 1181578-71-1)
- Trazodone Hydrochloride EP Impurity C (CAS 1263278-77-8)
- Trazodone Impurity 4 (CAS 1263278-79-0)
- Trazodone EP Impurity D HCl (CAS 1263278-80-3)
- Trazodone Hydrochloride EP Impurity J (CAS 1263358-12-8)
- Trazodone EP Impurity D (CAS 1263358-13-9)
- Trazodone EP Impurity E (CAS 1346599-35-6)
Recommended Standards
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- 7-Ethoxy-4,6-dihydroxyquinoline-3-carbonitrile (CAS 56606-26-9)
- 4-[(1Z)-{[(4-fluorophenyl)methoxy]imino}methyl]-2-[(4-methoxyphenyl)methyl]-1,2,3,4-tetrahydroisoquinoline-1,3-dione (CAS 303986-08-5)
- 3-Hydroxypropyl methacrylate (CAS 2761-09-3)
- 7-Hydroxyspiro[2.5]oct-6-en-5-one (CAS 1423046-30-3)
- CBP501 Affinity Peptide trifluoroacetate salt (CAS 1351804-17-5)
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