Trazodone Hydrochloride EP Impurity C CAS 1263278-77-8
| CAS No. | 1263278-77-8 |
| Molecular Formula | C19H22ClN5O |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 408.33 g/mol gives Trazodone Hydrochloride EP Impurity C distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
Trazodone Hydrochloride EP Impurity C (CAS 1263278-77-8) is a certified pharmaceutical impurity reference standard with the molecular formula C19H22ClN5OHCl and a molecular weight of 408.33 g/mol.
The molecular framework of Trazodone Hydrochloride EP Impurity C (C19H22ClN5OHCl) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C19H22ClN5O HCl |
| Molecular Weight | 408.33 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 5 |
Related Trazodone Standards
- Trazodone Impurity N13 (CAS 101364-27-6)
- Trazodone D6 (CAS 1181578-48-2)
- Trazodone-d6 Hydrochloride (CAS 1181578-71-1)
- Trazodone Impurity 4 (CAS 1263278-79-0)
- Trazodone EP Impurity D HCl (CAS 1263278-80-3)
- Trazodone Hydrochloride EP Impurity J (CAS 1263358-12-8)
- Trazodone EP Impurity D (CAS 1263358-13-9)
- Trazodone EP Impurity E (CAS 1346599-35-6)
Recommended Standards
- Luliconazole impurity 25 (CAS CATO-C4X-285325)
- Ceftazidime Impurity 73 (CAS CATO-C4X-121273)
- Pantoprazole Impurity 78 (CAS CATO-C4X-139978)
- 2,3,4,8-Tetrabromodibenzo[b,d]furan (CAS 617707-87-6)
- N-(4-chlorophenyl)-1-(2,4-difluorophenyl)-5-methyl-1H-1,2,4-triazole-3-carboxamide (CAS 321431-62-3)
- 2-Bromo-3-iodoprop-1-ene (CAS 111036-04-5)
- tert-Butyl 3-{[(pyridin-2-yl)methyl]amino}propanoate (CAS 1221342-71-7)
- 2-((R)-2-(Hydroxymethyl)pyrrolidin-1-yl)-N-(1-methoxypropan-2-yl)acetamide (CAS 1240669-99-1)
- Di-tert-butyl 1,3-phenylenedicarbamate (CAS 59255-77-5)
- Tirzepatide Impurity 33 (CAS CATO-C4X-324033)
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