Hydroxychloroquine Impurity 47 CAS CATO-C4X-183547
| CAS No. | CATO-C4X-183547 |
| Molecular Formula | C18H26ClN3O |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Hydroxychloroquine Impurity 47 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
CATO supplies Hydroxychloroquine Impurity 47 (CAS CATO-C4X-183547), a pharmacopoeial impurity reference standard (molecular formula C18H26ClN3OH2O4S, MW 433.95 g/mol) used for the identification and quantification of trace impurities in APIs.
Hydroxychloroquine Impurity 47 (C18H26ClN3OH2O4S) contains a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C18H26ClN3O H2O4S |
| Molecular Weight | 433.95 g/mol |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 1 |
Related Hydroxychloroquine Standards
- Hydroxychloroquine Impurity 75 (CAS 100713-49-3)
- Hydroxychloroquine EP Impurity B (CAS 103152-84-7)
- Hydroxychloroquine EP Impurity B Hydrogen sulfate (CAS 103152-84-7(free base))
- Hydroxychloroquine EP Impurity E (CAS 10500-64-8)
- Hydroxychloroquine Impurity 32 (CAS 106007-99-2)
- Hydroxychloroquine Impurity 30 (CAS 1077-74-3)
- Hydroxychloroquine Impurity 53 (CAS 109-83-1)
- Hydroxychloroquine D5 (CAS 118-42-3(Unlabelled))
Recommended Standards
- Doxycycline EP Impurity B（HCl） (CAS 3963-95-9)
- Ceftazidime Impurity 50 (CAS 1924627-99-5)
- Ketoconazole impurity 34 (CAS CATO-C4X-147234)
- Sotolasib (CAS 2296729-00-3)
- 53120-07-3 Phosgene-13C solution DTXSID30481025 (CAS 53120-07-3)
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Why CATO?
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